40 Result(s)

Article

Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion

We have previously identified an unsuspected role for GJB3 showing that the deficiency of this connexin protein induces aneuploidy in human and murine cells and accelerates cell transformation as well as tumor...

Junnan Liu, Xue Wang, Wencheng Jiang, Anca Azoitei… in Cellular & Molecular Biology Letters (2024)

Article

Erratum zu: Chancen der PSMA(prostataspezifisches Membranantigen)-Hybridbildgebung beim Prostatakarzinom

Anna-Sophie Strauß, Christian Bolenz, Ambros J. Beer, Friedemann Zengerling… in Die Urologie (2024)

Article

Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics

We have recently shown that loss of ORP3 leads to aneuploidy induction and promotes tumor formation. However, the specific mechanisms by which ORP3 contributes to ploidy-control and cancer initiation and progr...

Xue Wang, Junnan Liu, Anca Azoitei, Tim Eiseler… in Cellular and Molecular Life Sciences (2023)

Article

Xpert bladder cancer monitor to predict the need for a second TURB (MoniTURB trial)

To determine whether Xpert bladder cancer monitor, a noninvasive PCR-based biomarker test, can predict the need for 2nd transurethral resection of the bladder (TURB) better than clinical assessment. Patients s...

Johannes Breyer, Markus Eckstein, Danijel Sikic, Felix Wezel… in Scientific Reports (2023)

Article

TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration

The reactivation of genetic programs from early development is a common mechanism for injury-induced organ regeneration. T-box 3 (TBX3) is a member of the T-box family of transcription factors previously shown...

Michael Karl Melzer, Silvia Schirge, Johann Gout, Frank Arnold… in BMC Biology (2023)

Article

Contemporary options and future perspectives: three examples highlighting the challenges in testicular cancer imaging

One of the main issues in testicular germ cell tumors (TGCTs) management is to reduce the necessary amount of treatment to achieve cure. Excess treatment burden may arise from late diagnosis of the primary as ...

Gamal Anton Wakileh, Christian Ruf, Axel Heidenreich… in World Journal of Urology (2022)

Article

Deep learning-based classification of blue light cystoscopy imaging during transurethral resection of bladder tumors

Bladder cancer is one of the top 10 frequently occurring cancers and leads to most cancer deaths worldwide. Recently, blue light (BL) cystoscopy-based photodynamic diagnosis was introduced as a unique technolo...

Nairveen Ali, Christian Bolenz, Tilman Todenhöfer, Arnulf Stenzel… in Scientific Reports (2021)

Article

Subtype specific expression and survival prediction of pivotal lncRNAs in muscle invasive bladder cancer

Comprehensive transcriptome expression analyses of bladder cancer revealed distinct lncRNA clusters with differential molecular and clinical characteristics. In this study, pivotal lncRNAs were assessed for th...

Sebastien Rinaldetti, Thomas Stefan Worst, Eugen Rempel… in Scientific Reports (2020)

Article

Interobserver variability, detection rate, and lesion patterns of ⁶⁸Ga-PSMA-11-PET/CT in early-stage biochemical recurrence of prostate cancer after radical prostatectomy

⁶⁸Ga-PSMA-11-PET/CT is increasingly used in early-stage biochemical recurrence of prostate cancer to detect potential lesions for an individualized radiotherapy concept. However, subtle findings especially conce....

Jonathan Miksch, Dirk Bottke, Thomas Krohn… in European Journal of Nuclear Medicine and M… (2020)

Article

A multicenter paper-based and web-based system for collecting patient-reported outcome measures in patients undergoing local treatment for prostate cancer: first experiences

To give an overview of the multicenter Prostate Cancer Outcomes (PCO) study, involving paper-based and web-based collection of patient-reported outcome measures (PROM) in patients undergoing local treatment fo...

Christoph Kowalski, Rebecca Roth, Günther Carl… in Journal of Patient-Reported Outcomes (2020)

Article

Correction: Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Ramona Willbold, Katharina Wirth, Thomas Martini, Holger Sültmann… in Cell Death & Disease (2020)

Article

Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation and PCa progression in mice. Curiously, low expression of hepsin is associated wi...

Ramona Willbold, Katharina Wirth, Thomas Martini, Holger Sültmann… in Cell Death & Disease (2019)

Article

Postoperative elective pelvic nodal irradiation compared to prostate bed irradiation in locally advanced prostate cancer – a retrospective analysis of dose-escalated patients

It is uncertain if whole-pelvic irradiation (WPRT) in addition to dose-escalated prostate bed irradiation (PBRT) improves biochemical progression-free survival (bPFS) after prostatectomy for locally advanced t...

Carola Link, Patrick Honeck, Akiko Makabe, Frank Anton Giordano… in Radiation Oncology (2019)