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Article
Open AccessKidney double positive T cells have distinct characteristics in normal and diseased kidneys
Multiple types of T cells have been described and assigned pathophysiologic functions in the kidneys. However, the existence and functions of TCR+CD4+CD8+ (double positive; DP) T cells are understudied in norm...
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Article
Open AccessEvidence and emerging trends in local therapy for metastatic hormone-sensitive prostate cancer: a narrative review
Metastatic hormone-sensitive prostate cancer (mHSPC) displays both simultaneous and sequential patterns of metastasis, emphasizing a comprehensive treatment approach that integrates both local therapy and syst...
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Article
Open AccessImmunomodulatory response to neoadjuvant nivolumab in non-metastatic clear cell renal cell carcinoma
Novel perioperative strategies are needed to reduce recurrence rates in patients undergoing nephrectomy for high-risk, non-metastatic clear cell renal cell carcinoma (ccRCC). We conducted a prospective, phase ...
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Article
Assessment of Prostate and Bladder Cancer Genomic Biomarkers Using Artificial Intelligence: a Systematic Review
The aim of the systematic review is to assess AI’s capabilities in the genetics of prostate cancer (PCa) and bladder cancer (BCa) to evaluate target groups for such analysis as well as to assess its prospects ...
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Article
A systematic review and meta-analysis of artificial intelligence diagnostic accuracy in prostate cancer histology identification and grading
Artificial intelligence (AI) is a promising tool in pathology, including cancer diagnosis, subty**, grading, and prognostic prediction.
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Article
Open AccessSingle cell and spatial transcriptomics analysis of kidney double negative T lymphocytes in normal and ischemic mouse kidneys
T cells are important in the pathogenesis of acute kidney injury (AKI), and TCR+CD4-CD8- (double negative-DN) are T cells that have regulatory properties. However, there is limited information on DN T cells compa...
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Article
Open AccessClinical value of cholinesterase in patients treated with radical nephroureterectomy for upper urinary tract carcinoma
To evaluate the prognostic value and the clinical impact of preoperative serum cholinesterase (ChoE) levels on decision-making in patients treated with radical nephroureterectomy (RNU) for clinically non-metas...
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Article
Molecular differences in renal cell carcinoma between males and females
The disparity in renal cell carcinoma (RCC) risk and treatment outcome between males and females is well documented, but the underlying molecular mechanisms remain poorly elucidated.
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Article
The shifting treatment paradigm of metastatic renal cell carcinoma
The treatment landscape of renal cell carcinoma is rapidly evolving, especially with the introduction and approval of immune checkpoint inhibitor combination therapies. Clinical trial data show substantial imp...
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Article
Open AccessDeterminants of renal cell carcinoma invasion and metastatic competence
Metastasis is the principal cause of cancer related deaths. Tumor invasion is essential for metastatic spread. However, determinants of invasion are poorly understood. We addressed this knowledge gap by levera...
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Article
Decision-making in active surveillance in kidney cancer: current trends and future urine and tissue markers
Surveillance for small renal masses is a growing choice of management amongst physicians and patients. These decisions, however, can be difficult as patient factors and tumor factors may blur the line between ...
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Article
Interethnic differences in the impact of body mass index on upper tract urothelial carcinoma following radical nephroureterectomy
Inconsistent prognostic implications of body mass index (BMI) in upper tract urothelial carcinoma (UTUC) have been reported across different ethnicities. In this study, we aimed to analyze the oncologic role o...
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Chapter
Nephroureterectomy for Upper Tract Urothelial Carcinoma: Indications and Technique
Radical nephroureterectomy (RNU) remains the gold standard treatment for upper tract urothelial carcinoma (UTUC). In the present chapter, we discuss indications and preparation for surgery, including the use a...
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Chapter
Using Urinary Biomarkers in Urothelial Carcinoma of the Bladder and Upper Tracts
Bladder cancer is the most expensive cancer to manage yet available diagnostic tools continue to harbor many limitations. In fact, the gold standard tool in bladder cancer diagnosis and surveillance is cystosc...
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Article
Temperature changes during laser lithotripsy with Ho:YAG laser and novel Tm-fiber laser: a comparative in-vitro study
The aim of this study was to compare the thermal effects of Ho:YAG and Tm-fiber lasers during lithotripsy in an in-vitro model via real-time temperature measurement.
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Article
Multidimensional outcomes of suburethral synthetic midurethral sling removal
To report multidimensional outcomes encompassing pain, dyspareunia, and recurrent urinary tract infections (UTIs), following suburethral sling removal (SSR) of synthetic midurethral slings (MUS) placed for fem...
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Article
Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study
To evaluate the prognostic value of BRCA1-associated protein-1 (BAP1) expression in upper tract urothelial carcinoma (UTUC), as BAP1 mutations have been associated with prognostic implications in urologic and non...
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Article
Open AccessComparison of clinicopathologic characteristics, epigenetic biomarkers and prognosis between renal pelvic and ureteral tumors in upper tract urothelial carcinoma
There's no consensus about the difference between renal pelvic and ureteral tumors in terms of clinical features, pathological outcomes, epigenetic biomarkers and prognosis.
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Chapter
Post-prostatectomy Incontinence: Introduction and Prevalence
Urinary incontinence after prostatectomy is a significant issue that can affect the quality of life in men who are undergoing treatment for prostate cancer. With the growing number of radical prostatectomies p...
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Article
Anti-inflammatory use may not negatively impact oncologic outcomes following intravesical BCG for high-grade non-muscle-invasive bladder cancer
To evaluate whether anti-inflammatory agents affect outcomes in patients receiving intravesical BCG therapy for high-grade (HG) non-muscle-invasive bladder cancer (NMIBC).
