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Article
Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer
Epithelial-mesenchymal transition (EMT) is a driving force in promoting malignant cancer, including initiation, growth, and metastasis. EMT is a dynamic process that can undergo a mesenchymal-epithelial transi...
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Article
Open AccessSubtype specific expression and survival prediction of pivotal lncRNAs in muscle invasive bladder cancer
Comprehensive transcriptome expression analyses of bladder cancer revealed distinct lncRNA clusters with differential molecular and clinical characteristics. In this study, pivotal lncRNAs were assessed for th...
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Article
Correction: High-risk additional chromosomal abnormalities at low blast counts herald death by CML
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessHigh-risk additional chromosomal abnormalities at low blast counts herald death by CML
Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a time...
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Article
Open AccessFOXM1 predicts disease progression in non-muscle invasive bladder cancer
The proto-oncogene forkhead box M1 (FOXM1) is associated with poor survival in many cancers. The impact of FOXM1 expression on progression-free survival (PFS) of non-muscle invasive bladder cancer (NMIBC) has ...
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Article
Open AccessDefining therapy goals for major molecular remission in chronic myeloid leukemia: results of the randomized CML Study IV
Major molecular remission (MMR) is an important therapy goal in chronic myeloid leukemia (CML). So far, MMR is not a failure criterion according to ELN management recommendation leading to uncertainties when t...
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Article
Impact of unbalanced minor route versus major route karyotypes at diagnosis on prognosis of CML
Major route additional cytogenetic aberrations (ACA) at diagnosis of chronic myeloid leukaemia (CML) indicate an increased risk of progression and shorter survival. Since major route ACA are almost always unba...