In-Vitro Diagnostic Devices
Introduction to Current Point-of-Care Diagnostic Devices
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Open AccessFluorescence-based reagent and spectrum-based optical reader for lactoferrin detection in tears: differentiating Sjögren’s syndrome from non-Sjögren’s dry eye syndrome
Identification of an early biomarker and effective testing device to differentiate dry eye disease secondary to autoimmune disease (Sjögren’s syndrome dry eye disease) from non-Sjögren’s dry eye disease are pr...
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Open AccessA booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants
With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing effi...
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Transdermal drug delivery systems for fighting common viral infectious diseases
Transdermal drug delivery systems (TDDS) have many advantages and represent an excellent alternative to oral delivery and hypodermic injections. TDDS are more convenient and less invasive tools for disease and...
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Open AccessSmall-volume detection: platform developments for clinically-relevant applications
Biochemical analysis of human body fluids is a frequent and fruitful strategy for disease diagnosis. Point-of-care (POC) diagnostics offers the tantalizing possibility of providing rapid diagnostic results in ...
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Open AccessAccelerated corneal endothelial cell loss in two patients with granulomatosis with polyangiitis following phacoemulsification
Generally, the loss rate of human endothelial cells (HCEC) in routine cataract surgery is 8.5%. When the corneal endothelial cells density (ECD) drops, the HCEC may decompensate to keep cornea dehydration whic...
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Bioengineering of Human Corneal Endothelial Cells from Single- to Four-Dimensional Cultures
To summarize the recent advances of clinical and preclinical studies for corneal endothelial tissue bioengineering.
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Open AccessSmall-volume point-of-care analytical methods
Detecting clinically relevant diagnostic biomarkers, suitable for point-of-care detection, may facilitate rapid treatment and prevention of disease. However, medical diagnosis for which there are limited quant...
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Open AccessThe effect of bone inhibitors on periosteum-guided cartilage regeneration
The regeneration capacity of knee cartilage can be enhanced by applying periosteal grafts, but this effect varies depending on the different sources of the periosteal grafts applied for cartilage formation. Ti...
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Open AccessZebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells
Sarcomeric signaling complexes are important to sustain proper sarcomere structure and function, however, the mechanisms underlying these processes are not fully elucidated. In a gene trap experiment, we found...
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Open AccessRelationship between Porcine Sperm Motility and Sperm Enzymatic Activity using Paper-based Devices
Mammalian sperm motility has traditionally been analyzed to determine fertility using computer-assisted semen analysis (CASA) systems. To develop low-cost and robust male fertility diagnostics, we created a pa...
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Open AccessCorrection: Corrigendum: Paper-based CRP Monitoring Devices
Scientific Reports 6: Article number: 38171; published online: 02 December 2016; updated: 16 March 2017 The original version of this Article contained errors in the spelling of the authors Chung-Yuh Tzeng and ...
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Open AccessPaper-based CRP Monitoring Devices
Here, we discuss the development of a paper-based diagnostic device that is inexpensive, portable, easy-to-use, robust, and capable of running simultaneous tests to monitor a relevant inflammatory protein for ...
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Open AccessDetection of aqueous VEGF concentrations before and after intravitreal injection of anti-VEGF antibody using low-volume sampling paper-based ELISA
Intraocular vascular endothelial growth factor (VEGF) levels play an important role in the pathogenesis of blindness-related diseases, such as age-related macular degeneration (AMD). Here, we aimed to develop ...
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Open AccessOsteogenic differentiation of preosteoblasts on a hemostatic gelatin sponge
Bone tissue engineering provides many advantages for repairing skeletal defects. Although many different kinds of biomaterials have been used for bone tissue engineering, safety issues must be considered when ...
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Fabricating small-scale, curved, polymeric structures for biological applications using a combination of photocurable/thermocurable polydimethylsiloxane and phase interactions
This paper describes an easy-to-handle technique for creating curved, millimetrically scaled polymeric structures in order to develop in vitro cell culture devices for biologically relevant applications. For t...
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Book
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Chapter
Glucose Sensor and Its Potential Directions
This chapter elucidates diagnostic technological turnover and examines the breadth of and advances in diagnostic devices from plain to complex, but rather friendly, approaches. Most recent developments in diag...
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Chapter
Introduction to In Vitro Diagnostic Devices
Healthcare investment keeps on increasing substantially in recent years. Such investment has also focused on fighting major diseases, enabled by the novel invention of cost-effective and valid drug development...
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Low-cost In Vitro Diagnostic Technologies
This chapter introduces current trends in low-cost in vitro diagnostic technologies for resource-limited settings around the world. To date, the focus of diagnostics research has been to expand and support the...
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Polymeric-Based In Vitro Diagnostic Devices
Lab-on-a-chip (LOC) systems have been a key component of current in vitro diagnostics (IVD) research activity. Such systems usually employ specific flow patterns and create nanoliter-scale space for fluidic ma...
