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    Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

    Human orexin receptors (hOX1R and hOX2R) are GPCRs involved in sleep regulation. Structures of hOX1R bound to a selective antagonist or to a dual antagonist, functional assays and computational analyses reveal th...

    Jie Yin, Kerim Babaoglu, Chad A Brautigam in Nature Structural & Molecular Biology (2016)

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    Mechanism of actin filament nucleation by the bacterial effector VopL

    VopL is a bacterial actin nucleation factor that induces actin stress fibers when injected by bacteria into eukaryotic host cells. Biochemical and structural analyses of VopL-mediated actin nucleation suggest ...

    Bingke Yu, Hui-Chun Cheng, Chad A Brautigam in Nature Structural & Molecular Biology (2011)

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    Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

    Histone methylation regulates diverse chromatin-templated processes, including transcription. The recent discovery of the first histone lysine–specific demethylase (LSD1) has changed the long-held view that hi...

    Maojun Yang, Jeffrey C Culhane in Nature Structural & Molecular Biology (2007)

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    Side chain and backbone contributions of Phe508 to CFTR folding

    Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an integral membrane protein, cause cystic fibrosis (CF). The most common CF-causing mutant, deletion of Phe508, fails to properly f...

    Patrick H Thibodeau, Chad A Brautigam in Nature Structural & Molecular Biology (2005)