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  1. No Access

    Article

    Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii

    Carbapenem-resistant Acinetobacter baumannii infections have limited treatment options. Synthesis, transport and placement of lipopolysaccharide or lipooligosaccharide (LOS) in the outer membrane of Gram-negative...

    Hao Wang, Andrii Ishchenko, Jason Skudlarek, Pamela Shen… in Nature Microbiology (2024)

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    Article

    Structural basis for selectivity and diversity in angiotensin II receptors

    The angiotensin II receptors AT1R and AT2R serve as key components of the renin–angiotensin–aldosterone system. AT1R has a central role in the regulation of blood pressure, but the function of AT2R is unclear and...

    Haitao Zhang, Gye Won Han, Alexander Batyuk, Andrii Ishchenko, Kate L. White… in Nature (2017)

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    Article

    Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

    Human orexin receptors (hOX1R and hOX2R) are GPCRs involved in sleep regulation. Structures of hOX1R bound to a selective antagonist or to a dual antagonist, functional assays and computational analyses reveal th...

    Jie Yin, Kerim Babaoglu, Chad A Brautigam… in Nature Structural & Molecular Biology (2016)

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    Article

    Deconstructing fragment-based inhibitor discovery

    Kerim Babaoglu, Brian K Shoichet in Nature Chemical Biology (2006)