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Article
Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis
Semisynthetic constructs of protein kinase CK2 incorporating nonhydrolyzable post-translational modifications now demonstrate the interplay between phosphorylation and glycosylation in regulating CK2 stability...
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Article
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation
Histone methylation regulates diverse chromatin-templated processes, including transcription. The recent discovery of the first histone lysine–specific demethylase (LSD1) has changed the long-held view that hi...