29 Result(s)
within
Catherine Brenner
English
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Article
Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have ...
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Article
Phenolic Metabolites Modulate Cardiomyocyte Beating in Response to Isoproterenol
Cardiovascular disease (CVD) is a public health concern, and the third cause of death worldwide. Several epidemiological studies and experimental approaches have demonstrated that consumption of polyphenol-enr...
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Article
Open AccessAnticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death
Even though cell death modalities elicited by anticancer chemotherapy and radiotherapy have been extensively studied, the ability of anticancer treatments to induce non-cell-autonomous death has never been inv...
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Article
Open AccessMolecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives....
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Reference Work Entry In depth
ANT
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Chapter
Mitochondrial Regulation of Cell Death
Mitochondria are multifaceted organelles exerting vital as well as lethal functions within eukaryotic cells. When fueled with substrates and oxygen, mitochondria govern metabolic pathways, regulate calcium flu...
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Reference Work Entry In depth
Mitochondrial Membrane Permeabilization in Apoptosis
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Living Reference Work Entry In depth
ANT
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Protocol
Enzymatic Assays for Probing Mitochondrial Apoptosis
Isolated mitochondria are an invaluable analytical tool to probe mitochondrial function and evaluate apoptosis induction via the so-called mitochondrial pathway. Irrespective of their tissue origin (e.g., hear...
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Living Reference Work Entry In depth
Mitochondrial Membrane Permeabilization in Apoptosis
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Article
Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2
A high resistance and heterogeneous response to conventional anti-cancer chemotherapies characterize malignant cutaneous melanoma, the most aggressive and deadly form of skin cancer. Withaferin A (WFA), a with...
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Article
Open AccessCarbon monoxide prevents hepatic mitochondrial membrane permeabilization
Low concentrations of carbon monoxide (CO) protect hepatocytes against apoptosis and confers cytoprotection in several models of liver. Mitochondria are key organelles in cell death control via their membrane per...
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Reference Work Entry In depth
Mitochondrial Membrane Permeabilization in Apoptosis
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Article
A flavivirus protein M-derived peptide directly permeabilizes mitochondrial membranes, triggers cell death and reduces human tumor growth in nude mice
Dengue viruses belong to the Flavivirus family and are responsible for hemorrhagic fever in Human. Dengue virus infection triggers apoptosis especially through the expression of the small membrane (M) protein....
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Reference Work Entry In depth
Mitochondrial Membrane Permeabilization in Apoptosis
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Article
Methods for the assessment of mitochondrial membrane permeabilization in apoptosis
Mitochondrial membrane permeabilization (MMP) is considered as the “point-of-no-return” in numerous models of programmed cell death. Indeed, mitochondria determine the intrinsic pathway of apoptosis, and play ...
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Article
Acidic extracellular pH shifts colorectal cancer cell death from apoptosis to necrosis upon exposure to propionate and acetate, major end-products of the human probiotic propionibacteria
The human probiotic Propionibacterium freudenreichii kills colorectal adenocarcinoma cells through apoptosis in vitro via its metabolites, the short chain fatty acids (SCFA), acetate and propionate. However, the ...
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Article
Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis
In the present study, the toxicity of yperite, SM, and its structural analogue mechlorethamine, HN2, was investigated in a human bronchial epithelial cell line 16HBE. Cell detachment was initiated by caspase-2...
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Article
Dynamic evolution of the adenine nucleotide translocase interactome during chemotherapy-induced apoptosis
The mitochondrial permeability transition pore complex (PTPC) is involved in the control of the mitochondrial membrane permeabilization during apoptosis, necrosis and autophagy. Indeed, the adenine nucleotide ...
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Article
The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family
N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a potent chemopreventive agent whose effect has been suggested to involve apoptosis induction. 4-HPR induces a loss of the mitochondrial transmembrane poten.....
