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  1. Article

    Open Access

    Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor

    Nowadays, effects of fine particulate matter (PM2.5) are well-documented and related to oxidative stress and pro-inflammatory response. Nevertheless, epidemiological studies show that PM2.5 exposure is correlated...

    Ioana Ferecatu, Marie-Caroline Borot, Camille Bossard… in Particle and Fibre Toxicology (2010)

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  2. Article

    Open Access

    Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells

    Increasing environmental and occupational exposures to nanoparticles (NPs) warrant deeper insight into the toxicological mechanisms induced by these materials. The present study was designed to characterize th...

    Salik Hussain, Leen CJ Thomassen, Ioana Ferecatu… in Particle and Fibre Toxicology (2010)

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  3. No Access

    Article

    Oxaliplatin-induced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA

    We previously established a model of acquired oxaliplatin resistance derived from the HCT116 oxaliplatin-sensitive cell line (HCT116S) and consisting in two resistant clones (HCT116R1, HCT116R2) and their tota...

    Isabelle Gourdier, Laure Crabbe, Karine Andreau, Bernard Pau, Guido Kroemer in Oncogene (2004)

  4. No Access

    Article

    Cell death by mitotic catastrophe: a molecular definition

    The current literature is devoid of a clearcut definition of mitotic catastrophe, a type of cell death that occurs during mitosis. Here, we propose that mitotic catastrophe results from a combination of defici...

    Maria Castedo, Jean-Luc Perfettini, Thomas Roumier, Karine Andreau, Rene Medema… in Oncogene (2004)

  5. No Access

    Article

    The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family

    N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) is a potent chemopreventive agent whose effect has been suggested to involve apoptosis induction. 4-HPR induces a loss of the mitochondrial transmembrane poten.....

    Patricia Boya, Maria Celia Morales, Rosa-Ana Gonzalez-Polo, Karine Andreau… in Oncogene (2003)

  6. No Access

    Article

    Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine

    Hydroxychloroquine (HCQ) is a lysosomotropic amine with cytotoxic properties. Here, we show that HCQ induces signs of lysosomal membrane permeabilization (LMP), such as the decrease in the lysosomal pH gradien...

    Patricia Boya, Rosa-Ana Gonzalez-Polo, Delphine Poncet, Karine Andreau… in Oncogene (2003)

  7. Article

    IL-4 inhibits apoptosis and prevents mitochondrial damage without inducing the switch to necrosis observed with caspase inhibitors

    We previously demonstrated that the broad-spectrum caspase inhibitor, zVAD-fmk, totally deviated apoptosis to necrosis in B lymphocytes. We report here that, in contrast with zVAD-fmk, IL-4 protected B cells f...

    Christophe Lemaire, Karine Andréau… in Cell Death & Differentiation (1999)

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