16 Result(s)
within
Davide Degli Esposti
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Electron-activated dissociation (EAD) for the complementary annotation of metabolites and lipids through data-dependent acquisition analysis and feature-based molecular networking, applied to the sentinel amphipod Gammarus fossarum
The past decades have marked the rise of metabolomics and lipidomics as the -omics sciences which reflect the most phenotypes in living systems. Mass spectrometry–based approaches are acknowledged for both qua...
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Open AccessLow disorder and high valley splitting in silicon
The electrical characterisation of classical and quantum devices is a critical step in the development cycle of heterogeneous material stacks for semiconductor spin qubits. In the case of silicon, properties s...
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Article
Editorial trend: adverse outcome pathway (AOP) and computational strategy — towards new perspectives in ecotoxicology
The adverse outcome pathway (AOP) has been conceptualized in 2010 as an analytical construct to describe a sequential chain of causal links between key events, from a molecular initiating event leading to an a...
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Open AccessOrgan-oriented proteogenomics functional atlas of three aquatic invertebrate sentinel species
Proteogenomic methodologies have enabled the identification of protein sequences in wild species without annotated genomes, shedding light on molecular mechanisms affected by pollution. However, proteomic reso...
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Open AccessAuthor Correction: Reducing charge noise in quantum dots by using thin silicon quantum wells
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Open AccessReducing charge noise in quantum dots by using thin silicon quantum wells
Charge noise in the host semiconductor degrades the performance of spin-qubits and poses an obstacle to control large quantum processors. However, it is challenging to engineer the heterogeneous material stack...
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Open AccessDetermination of biomarkers threshold values and illustration of their use for the diagnostic in large-scale freshwater biomonitoring surveys
Several biomarkers developed from freshwater sentinel species are used to complement chemical assessment of freshwater ecosystems and improve the evaluation of their contamination levels. While active biomonit...
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Open AccessCombining proteogenomics and metaproteomics for deep taxonomic and functional characterization of microbiomes from a non-sequenced host
Metaproteomics of gut microbiomes from animal hosts lacking a reference genome is challenging. Here we describe a strategy combining high-resolution metaproteomics and host RNA sequencing (RNA-seq) with genera...
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Open AccessDe novo transcriptomes of 14 gammarid individuals for proteogenomic analysis of seven taxonomic groups
Gammarids are amphipods found worldwide distributed in fresh and marine waters. They play an important role in aquatic ecosystems and are well established sentinel species in ecotoxicology. In this study, we s...
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Open AccessCo-expression network analysis identifies gonad- and embryo-associated protein modules in the sentinel species Gammarus fossarum
Next generation sequencing and mass spectrometry technologies have recently expanded the availability of whole transcriptomes and proteomes beyond classical model organisms in molecular biology, even in absenc...
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Open AccessThe methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region
The Human Leucocyte Antigen (HLA) locus and other DNA sequence variants identified in Genome-Wide Association (GWA) studies explain around 50% of the heritability of celiac disease (CD). However, the pathogenesis...
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EXPOsOMICs: Meet-in-the-Middle and Network Perturbation
Systems biology has been driven by technology (the development of omics) and by statistical modelling and bioinformatics. We aim to bring biological thinking back. We suggest that three traditions of thought n...
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Open AccessmiR-500a-5p regulates oxidative stress response genes in breast cancer and predicts cancer survival
MicroRNAs (miRNAs) are small regulatory non-coding RNAs with a diversity of cellular functions, and are frequently dysregulated in cancer. Using a novel computational method (ActMir) that we recently developed, t...
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Open AccessUnique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas
Head and neck squamous cell carcinomas (HNSCCs) represent a heterogeneous group of cancers for which human papilloma virus (HPV) infection is an emerging risk factor. Previous studies showed promoter hypermeth...
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Open AccessAberrant DNA methylation of imprinted loci in hepatocellular carcinoma and after in vitro exposure to common risk factors
Hepatocellular carcinoma (HCC) is among the most frequent human malignancies and a major cause of cancer-related death worldwide. It is characterized by late detection and fast progression, and it is believed ...
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Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2
A high resistance and heterogeneous response to conventional anti-cancer chemotherapies characterize malignant cutaneous melanoma, the most aggressive and deadly form of skin cancer. Withaferin A (WFA), a with...
