24 Result(s)

Article

Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma

Pleomorphic xanthoastrocytoma (PXA) is a rare, superficially situated tumor that most frequently occurs in the temporal lobe of young adults and is often associated with seizures. It generally has a relativel...

Caterina Giannini, Deanne Hebrink, Bernd W. Scheithauer, Angelo P. Dei Tos… in Neurogenetics (2001)

Article

Cerebral angiitis mimicking posterior leukoencephalopathy

Posterior leukoencephalopathy typically denotes neurotoxicity from immunosuppressive agents, malignant hypertension or eclampsia. It has not been documented in central nervous system angiitis. We present thre...

Eelco F. M. Wijdicks, Edward M. Manno, Jimmy R. Fulgham… in Journal of Neurology (2003)

Article

Brainstem infarcts as an early manifestation of streptococcus anginosus meningitis

Background and Purpose: Vasculitis and infarcts are well-established sequelae of bacterial meningitis. However, early large-vessel involvement is rare, particularly within the brainstem. There ha...

Sung B. Lee, Lyell K. Jones, Caterina Giannini in Neurocritical Care (2005)

Article

Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade

Anaplastic oligoastrocytomas (AOA) are relatively uncommon high-grade gliomas. While oligodendroglial elements are thought to be associated with better outcomes, the magnitude of the difference is not clear.

Jan C. Buckner, Judith R. O’Fallon, Robert P. Dinapoli… in Journal of Neuro-Oncology (2007)

Article

Retrospective review of adjuvant chemotherapy for esthesioneuroblastoma

Background Esthesioneuroblastoma (ENB) is a rare tumor arising from the olfactory epithelium in the upper nasal cavity. Prior reviews have found efficacy of chemotherapy for high grade tumors in the advanced sett...

Alyx B. Porter, Dirk M. Bernold, Caterina Giannini… in Journal of Neuro-Oncology (2008)

Article

Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model

CpG methylation within the O6-methylguanine-DNA-methyltransferase (MGMT) promoter is associated with enhanced survival of glioblastoma multiforme (GBM) patients treated with temozolomide (TMZ). Although MGMT prom...

Gaspar J. Kitange, Brett L. Carlson, Ann C. Mladek… in Journal of Neuro-Oncology (2009)

Article

Atypical Acute Hemorrhagic Leukoencephalitis (Hurst’s disease) Presenting with Focal Hemorrhagic Brainstem Lesion

Acute hemorrhagic leukoencephalitis (AHL; Hurst’s disease) is a rare, severe, inflammatory CNS disease that is typically diffuse, multifocal and associated with petechial hemorrhage. The objective of this stud...

Nuhad E. Abou Zeid, Joseph D. Burns, Eelco F. M. Wijdicks… in Neurocritical Care (2010)

Article

Phase II NCCTG trial of RT + irinotecan and adjuvant BCNU plus irinotecan for newly diagnosed GBM

Irinotecan has radiosensitizing effects and shows synergism with nitrosoureas. We performed a Phase II study of RT and irinotecan, followed by BCNU plus irinotecan in newly-diagnosed GBM. The MTD for patients ...

Kurt A. Jaeckle, Karla V. Ballman, Caterina Giannini… in Journal of Neuro-Oncology (2010)

Article

Expression of CD74 in high grade gliomas: a potential role in temozolomide resistance

Temozolomide (TMZ) is the most effective chemotherapeutic agent for glioblastoma (GBM). Resistance to this methylating agent is linked to DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT). Howeve...

Gaspar J. Kitange, Brett L. Carlson, Mark A. Schroeder… in Journal of Neuro-Oncology (2010)

Article

The role of LAT1 in ¹⁸F-DOPA uptake in malignant gliomas

Positron emission tomography (PET) imaging with the amino acid tracer 6-¹⁸F-fluoro-l-3,4-dihydroxy-phenylalanine (¹⁸F-DOPA) may provide better spatial and functional information in human gliomas than CT or MRI al...

Ryan S. Youland, Gaspar J. Kitange, Timothy E. Peterson… in Journal of Neuro-Oncology (2013)

Article

Interlaboratory comparison of IDH mutation detection

Isocitrate dehydrogenase (IDH) mutational testing is becoming increasingly important. For this, robust and reliable assays are needed. We tested the variation of results between six laboratories of testing for...

Martin J. van den Bent, C. Hartmann, Matthias Preusser… in Journal of Neuro-Oncology (2013)

Article

Gliomatosis cerebri: clinical characteristics, management, and outcomes

Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution serie...

Selby Chen, Shota Tanaka, Caterina Giannini, Jonathan Morris… in Journal of Neuro-Oncology (2013)

Article

The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma

This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA). The impact of isocitrate dehydrogenase (IDH) status on the...

Sani H. Kizilbash, Caterina Giannini, Jesse S. Voss… in Journal of Neuro-Oncology (2014)

Article

Phase II trial of pre-irradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: long term results of RTOG BR0131

We report on the long-term results of a phase II study of pre-irradiation temozolomide followed by concurrent temozolomide and radiotherapy (RT) in patients with newly diagnosed anaplastic oligodendroglioma (A...

Michael A. Vogelbaum, Chen Hu, David M. Peereboom… in Journal of Neuro-Oncology (2015)

Article

Management of diffuse low-grade gliomas in adults — use of molecular diagnostics

Article

Prospective trial evaluating the sensitivity and specificity of 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (18F-DOPA) PET and MRI in patients with recurrent gliomas

Treatment-related changes can be difficult to differentiate from progressive glioma using MRI with contrast (CE). The purpose of this study is to compare the sensitivity and specificity of 18F-DOPA-PET and MRI...

Ryan S. Youland, Deanna H. Pafundi, Debra H. Brinkmann… in Journal of Neuro-Oncology (2018)

Article

Phase I-II trial of imatinib mesylate (Gleevec; STI571) in treatment of recurrent oligodendroglioma and mixed oligoastrocytoma. North central cancer treatment group study N0272 (ALLIANCE/NCCTG)

To evaluate the pharmacokinetics and efficacy of imatinib in patients with recurrent oligodendroglial tumors.

Kurt A. Jaeckle, S. K. Anderson, Erin L. Twohy, Jesse G. Dixon… in Journal of Neuro-Oncology (2019)

Article

Plenty of calcification: imaging characterization of polymorphous low-grade neuroepithelial tumor of the young

Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently described epileptogenic neoplasm. As the name implies, PLNTYs are indolent tumors most often encountered in the pediatric or youn...

Derek R. Johnson, Caterina Giannini, Robert B. Jenkins, Dong Kun Kim… in Neuroradiology (2019)

Chapter

Adult Primary Central Nervous System Vasculitis

Primary CNS vasculitis is an uncommon disorder of unknown cause that is restricted to brain and spinal cord. The median age of onset is 50 years. The neurological manifestations are diverse, but generally cons...

Carlo Salvarani, Robert D. Brown Jr… in Large and Medium Size Vessel and Single Or… (2021)