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  1. Article

    Open Access

    ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma

    Determining the balance between DNA double strand break repair (DSBR) pathways is essential for understanding treatment response in cancer. We report a method for simultaneously measuring non-homologous end jo...

    Daniel J. Laverty, Shiv K. Gupta, Gary A. Bradshaw… in Nature Communications (2024)

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  2. Article

    Open Access

    Integrated map** of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

    Therapeutic options for the treatment of glioblastoma remain inadequate despite concerted research efforts in drug development. Therapeutic failure can result from poor permeability of the blood-brain barrier,...

    Elizabeth C. Randall, Kristina B. Emdal, Janice K. Laramy… in Nature Communications (2018)

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  3. No Access

    Article

    Expression of CD74 in high grade gliomas: a potential role in temozolomide resistance

    Temozolomide (TMZ) is the most effective chemotherapeutic agent for glioblastoma (GBM). Resistance to this methylating agent is linked to DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT). Howeve...

    Gaspar J. Kitange, Brett L. Carlson, Mark A. Schroeder… in Journal of Neuro-Oncology (2010)

  4. No Access

    Article

    Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model

    CpG methylation within the O6-methylguanine-DNA-methyltransferase (MGMT) promoter is associated with enhanced survival of glioblastoma multiforme (GBM) patients treated with temozolomide (TMZ). Although MGMT prom...

    Gaspar J. Kitange, Brett L. Carlson, Ann C. Mladek… in Journal of Neuro-Oncology (2009)