24 Result(s)

Article

Hybrid tumors with perineurioma components: a systematic review of the literature and illustrative case

Hybrid peripheral nerve sheath tumors (HPNST) are a newly recognized class of peripheral nerve sheath tumor, composed of at least two areas characteristic of perineurioma, schwannoma, or neurofibroma. The lite...

Karina A. Lenartowicz, Dileep D. Monie, Kimberly K. Amrami… in Acta Neurochirurgica (2023)

Article

Histopathology and prognosis of germ cell tumors metastatic to brain: cohort study

Germ cell tumors (GCTs) are uncommon neoplasms predominantly arising in midline tissues. The prognostic significance of histopathology in predicting metastatic GCT behavior is poorly understood.

Hirokazu Takami, Christopher S. Graffeo, Avital Perry… in Journal of Neuro-Oncology (2021)

Article

Intracranial angiomatoid fibrous histiocytoma with rhabdoid features: a mimic of rhabdoid meningioma

Angiomatoid fibrous histiocytoma (AFH) is an uncommon soft-tissue neoplasm that arises mostly in the extremities of young people and generally carries a good prognosis. Intracranial location is unusual and fre...

M. Adelita Vizcaino, Caterina Giannini, Howard T. Chang… in Brain Tumor Pathology (2021)

Chapter

Adult Primary Central Nervous System Vasculitis

Primary CNS vasculitis is an uncommon disorder of unknown cause that is restricted to brain and spinal cord. The median age of onset is 50 years. The neurological manifestations are diverse, but generally cons...

Carlo Salvarani, Robert D. Brown Jr… in Large and Medium Size Vessel and Single Or… (2021)

Article

Plenty of calcification: imaging characterization of polymorphous low-grade neuroepithelial tumor of the young

Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently described epileptogenic neoplasm. As the name implies, PLNTYs are indolent tumors most often encountered in the pediatric or youn...

Derek R. Johnson, Caterina Giannini, Robert B. Jenkins, Dong Kun Kim… in Neuroradiology (2019)

Article

Phase I-II trial of imatinib mesylate (Gleevec; STI571) in treatment of recurrent oligodendroglioma and mixed oligoastrocytoma. North central cancer treatment group study N0272 (ALLIANCE/NCCTG)

To evaluate the pharmacokinetics and efficacy of imatinib in patients with recurrent oligodendroglial tumors.

Kurt A. Jaeckle, S. K. Anderson, Erin L. Twohy, Jesse G. Dixon… in Journal of Neuro-Oncology (2019)

Article

Prospective trial evaluating the sensitivity and specificity of 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (18F-DOPA) PET and MRI in patients with recurrent gliomas

Treatment-related changes can be difficult to differentiate from progressive glioma using MRI with contrast (CE). The purpose of this study is to compare the sensitivity and specificity of 18F-DOPA-PET and MRI...

Ryan S. Youland, Deanna H. Pafundi, Debra H. Brinkmann… in Journal of Neuro-Oncology (2018)

Article

Management of diffuse low-grade gliomas in adults — use of molecular diagnostics

Article

Phase II trial of pre-irradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: long term results of RTOG BR0131

We report on the long-term results of a phase II study of pre-irradiation temozolomide followed by concurrent temozolomide and radiotherapy (RT) in patients with newly diagnosed anaplastic oligodendroglioma (A...

Michael A. Vogelbaum, Chen Hu, David M. Peereboom… in Journal of Neuro-Oncology (2015)

Article

The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma

This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA). The impact of isocitrate dehydrogenase (IDH) status on the...

Sani H. Kizilbash, Caterina Giannini, Jesse S. Voss… in Journal of Neuro-Oncology (2014)

Article

Interlaboratory comparison of IDH mutation detection

Isocitrate dehydrogenase (IDH) mutational testing is becoming increasingly important. For this, robust and reliable assays are needed. We tested the variation of results between six laboratories of testing for...

Martin J. van den Bent, C. Hartmann, Matthias Preusser… in Journal of Neuro-Oncology (2013)

Article

Gliomatosis cerebri: clinical characteristics, management, and outcomes

Gliomatosis cerebri is a rare diffusely infiltrating primary neoplastic glial process of the brain. Our objective is to review clinical presentation, management, and outcome in a large single institution serie...

Selby Chen, Shota Tanaka, Caterina Giannini, Jonathan Morris… in Journal of Neuro-Oncology (2013)

Article

The role of LAT1 in ¹⁸F-DOPA uptake in malignant gliomas

Positron emission tomography (PET) imaging with the amino acid tracer 6-¹⁸F-fluoro-l-3,4-dihydroxy-phenylalanine (¹⁸F-DOPA) may provide better spatial and functional information in human gliomas than CT or MRI al...

Ryan S. Youland, Gaspar J. Kitange, Timothy E. Peterson… in Journal of Neuro-Oncology (2013)

Article

Expression of CD74 in high grade gliomas: a potential role in temozolomide resistance

Temozolomide (TMZ) is the most effective chemotherapeutic agent for glioblastoma (GBM). Resistance to this methylating agent is linked to DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT). Howeve...

Gaspar J. Kitange, Brett L. Carlson, Mark A. Schroeder… in Journal of Neuro-Oncology (2010)

Article

Phase II NCCTG trial of RT + irinotecan and adjuvant BCNU plus irinotecan for newly diagnosed GBM

Irinotecan has radiosensitizing effects and shows synergism with nitrosoureas. We performed a Phase II study of RT and irinotecan, followed by BCNU plus irinotecan in newly-diagnosed GBM. The MTD for patients ...

Kurt A. Jaeckle, Karla V. Ballman, Caterina Giannini… in Journal of Neuro-Oncology (2010)

Article

Atypical Acute Hemorrhagic Leukoencephalitis (Hurst’s disease) Presenting with Focal Hemorrhagic Brainstem Lesion

Acute hemorrhagic leukoencephalitis (AHL; Hurst’s disease) is a rare, severe, inflammatory CNS disease that is typically diffuse, multifocal and associated with petechial hemorrhage. The objective of this stud...

Nuhad E. Abou Zeid, Joseph D. Burns, Eelco F. M. Wijdicks… in Neurocritical Care (2010)

Article

Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model

CpG methylation within the O6-methylguanine-DNA-methyltransferase (MGMT) promoter is associated with enhanced survival of glioblastoma multiforme (GBM) patients treated with temozolomide (TMZ). Although MGMT prom...

Gaspar J. Kitange, Brett L. Carlson, Ann C. Mladek… in Journal of Neuro-Oncology (2009)

Article

Retrospective review of adjuvant chemotherapy for esthesioneuroblastoma

Background Esthesioneuroblastoma (ENB) is a rare tumor arising from the olfactory epithelium in the upper nasal cavity. Prior reviews have found efficacy of chemotherapy for high grade tumors in the advanced sett...

Alyx B. Porter, Dirk M. Bernold, Caterina Giannini… in Journal of Neuro-Oncology (2008)