5 Result(s)
within
Carlotta Tacconi
English
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Article
Open AccessSEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability
Innervation of the hypothalamic median eminence by Gonadotropin-Releasing Hormone (GnRH) neurons is vital to ensure puberty onset and successful reproduction. However, the molecular and cellular mechanisms und...
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Article
Open AccessKIT is dispensable for physiological organ vascularisation in the embryo
Blood vessels form vast networks in all vertebrate organs to sustain tissue growth, repair and homeostatic metabolism, but they also contribute to a range of diseases with neovascularisation. It is, therefore,...
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Article
Open AccessLETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C
Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. There is ample evidence that distinct types of vasculature undergo tight transcrip...
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Article
Open AccessEpigenetic regulation of the lineage specificity of primary human dermal lymphatic and blood vascular endothelial cells
Lymphatic and blood vascular endothelial cells (ECs) share several molecular and developmental features. However, these two cell types possess distinct phenotypic signatures, reflecting their different biologi...
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Article
Open AccessLymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis
MAFB is a transcription factor involved in the terminal differentiation of several cell types, including macrophages and keratinocytes. MAFB is also expressed in lymphatic endothelial cells (LECs) and is upreg...
