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Article
Associations amongst genes, molecules, cells, and organs in breast cancer metastasis
This paper is a cross fertilization of ideas about the importance of molecular aspects of breast cancer metastasis by basic scientists, a pathologist, and clinical oncologists at the Henry Ford Health symposiu...
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Protocol
Isolation and Fluorescent Labeling of Extracellular Vesicles from Cultured Tumor Cells
Extracellular vesicles (EVs), comprising exosomes, ectosomes, and apoptotic bodies, are an important component of molecular cell-to-cell communication, and are critically involved in the pathophysiology of var...
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Article
Open AccessLETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C
Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. There is ample evidence that distinct types of vasculature undergo tight transcrip...
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Article
Open AccessLymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis
MAFB is a transcription factor involved in the terminal differentiation of several cell types, including macrophages and keratinocytes. MAFB is also expressed in lymphatic endothelial cells (LECs) and is upreg...
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Reference Work Entry In depth
Biology of Melanoma Metastasis
Metastasis is the major cause of death in patients suffering from malignant melanoma, one of the most aggressive types of cancer. Local recurrence is rare in melanoma, but regional and distant metastasis, part...
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Living Reference Work Entry In depth
Biology of Melanoma Metastasis
Metastasis is the major cause of death in patients suffering from malignant melanoma, one of the most aggressive types of cancer. Local recurrence is rare in melanoma, but regional and distant metastasis, part...
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Article
Open AccessDistinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation
Vascular endothelial growth factors (VEGFs) and their receptors play crucial roles in the formation of blood and lymphatic vessels during embryogenesis, and also under pathologic conditions in the adult. Despi...
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Article
Lymphatic vessels: new targets for the treatment of inflammatory diseases
The lymphatic system plays an important role in the physiological control of the tissue fluid balance and in the initiation of immune responses. Recent studies have shown that lymphangiogenesis, the growth of ...
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Article
Open AccessαB-crystallin/HspB5 regulates endothelial–leukocyte interactions by enhancing NF-κB-induced up-regulation of adhesion molecules ICAM-1, VCAM-1 and E-selectin
αB-crystallin is a small heat shock protein, which has pro-angiogenic properties by increasing survival of endothelial cells and secretion of vascular endothelial growth factor A. Here we demonstrate an additi...
