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Article
Open AccessSequencing of human genomes with nanopore technology
Whole-genome sequencing (WGS) is becoming widely used in clinical medicine in diagnostic contexts and to inform treatment choice. Here we evaluate the potential of the Oxford Nanopore Technologies (ONT) MinION...
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Article
Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus
Chris Spencer, Eleanor Barnes and colleagues use human genoty** arrays and whole-genome viral sequencing to perform a systematic genome-to-genome study of 542 individuals chronically infected with hepatitis ...
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Article
Open AccessVirus genomics and evolution: the transformative effect of new technologies and multidisciplinary collaboration on virus research and outbreak management
The first Virus Genomics and Evolution Conference was held at the Wellcome Genome Campus in Hinxton, UK, 8–10 June 2016.
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Article
Open AccessMobile elements drive recombination hotspots in the core genome of Staphylococcus aureus
Horizontal gene transfer is an important driver of bacterial evolution, but genetic exchange in the core genome of clonal species, including the major pathogen Staphylococcus aureus, is incompletely understood. H...
