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Article
Open AccessTrust and the ethical challenges in the use of whole genome sequencing for tuberculosis surveillance: a qualitative study of stakeholder perspectives
Emerging genomic technologies promise more efficient infectious disease control. Whole genome sequencing (WGS) is increasingly being used in tuberculosis (TB) diagnosis, surveillance, and epidemiology. However...
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Article
Open AccessImmunosignature Analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
A random-sequence peptide microarray can interrogate serum antibodies in a broad, unbiased fashion to generate disease-specific immunosignatures. This approach has been applied to cancer detection, diagnosis o...
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Article
Towards a genomics-informed, real-time, global pathogen surveillance system
Despite the recommendations of many expert groups, public health surveillance systems have not yet improved to the point where emerging infectious threats can ...
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Article
Open AccessVirus genomics and evolution: the transformative effect of new technologies and multidisciplinary collaboration on virus research and outbreak management
The first Virus Genomics and Evolution Conference was held at the Wellcome Genome Campus in Hinxton, UK, 8–10 June 2016.
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Article
Open AccessStop** outbreaks with real-time genomic epidemiology
One of the most successful public health applications of next-generation sequencing is whole-genome sequencing of pathogens to not only detect and characterize outbreaks, but also to inform outbreak management...
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Article
Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis
Maha Farhat, Megan Murray and colleagues report whole-genome sequencing of 116 Mycobacterium tuberculosis strains selected to be representative of both global diversity and drug resistance. The authors develop a ...
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Article
Metagenomics for pathogen detection in public health
Traditional pathogen detection methods in public health infectious disease surveillance rely upon the identification of agents that are already known to be associated with a particular clinical syndrome. The e...
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Article
Open AccessSystems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro
Pandemic influenza H1N1 (pdmH1N1) virus causes mild disease in humans but occasionally leads to severe complications and even death, especially in those who are pregnant or have underlying disease. Cytokine re...
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Article
Open AccessRobust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
Activation of Toll-like receptors (TLRs) is widely accepted as an essential event for defence against infection. Many TLRs utilize a common signalling pathway that relies on activation of the kinase IRAK4 and ...
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Systems-Level Analyses of the Mammalian Innate Immune Response
The regulation of the innate immune response, our first line of defence against infectious disease, does not involve simple linear pathways but rather complex inter-connected networks of interactions, regulato...
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Article
Erratum: Methods for predicting bacterial protein subcellular localization
Nature Reviews Microbiology 4, 741–751 (2006) In the above article, there was an error in the true negative (TN) values provided in Table 2 for the PSORTb and Proteome Analyst programs. This error had no impac...
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Article
Methods for predicting bacterial protein subcellular localization
The prediction of a bacterial protein's subcellular localization can be of considerable aid to microbiological research. It can be used to infer potential func...
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Article
Open AccessAssessing the precision of high-throughput computational and laboratory approaches for the genome-wide identification of protein subcellular localization in bacteria
Identification of a bacterial protein's subcellular localization (SCL) is important for genome annotation, function prediction and drug or vaccine target identification. Subcellular fractionation techniques co...
