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Open AccessAuthor Correction: Comparative and demographic analysis of orang-utan genomes
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Open AccessSequencing of human genomes with nanopore technology
Whole-genome sequencing (WGS) is becoming widely used in clinical medicine in diagnostic contexts and to inform treatment choice. Here we evaluate the potential of the Oxford Nanopore Technologies (ONT) MinION...
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Open AccessInvestigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations
Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female lines, ...
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Correction: Corrigendum: Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes
Nature Communications 5: Article number: 3979 (2014); Published 9 June 2014; Updated 9 April 2015. The original version of this Article contained a typographical error in the spelling of the author Nicholas E....
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Open AccessIdentification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer
Although chemotherapy for prostate cancer (PCa) can improve patient survival, some tumours are chemo-resistant. Tumour molecular profiles may help identify the mechanisms of drug action and identify potential ...
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Open AccessLong non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes
Early reports indicate that long non-coding RNAs (lncRNAs) are novel regulators of biological responses. However, their role in the human innate immune response, which provides the initial defence against infe...
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Sequencing depth and coverage: key considerations in genomic analyses
The average depth of sequencing coverage can be defined theoretically as LN/G, where L is the read length, N is the number of reads and G is the haploid genome...
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Open AccessInsights into the evolution of Darwin’s finches from comparative analysis of the Geospiza magnirostris genome sequence
A classical example of repeated speciation coupled with ecological diversification is the evolution of 14 closely related species of Darwin’s (Galápagos) finches (Thraupidae, Passeriformes). Their adaptive rad...
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Open AccessEvidence for conserved post-transcriptional roles of unitary pseudogenes and for frequent bifunctionality of mRNAs
Recent reports have highlighted instances of mRNAs that, in addition to coding for protein, regulate the abundance of related transcripts by altering microRNA availability. These two mRNA roles - one mediated ...
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Open AccessInsights into hominid evolution from the gorilla genome sequence
Gorillas are humans’ closest living relatives after chimpanzees, and are of comparable importance for the study of human origins and evolution. Here we present the assembly and analysis of a genome sequence fo...
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Open AccessMouse genomic variation and its effect on phenotypes and gene regulation
We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory ...
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Open AccessThe genome of the green anole lizard and a comparative analysis with birds and mammals
The first non-avian reptile genome has been sequenced, that of the North American green anole lizard (Anolis carolinensis). The anole is an emerging model for the study of adaptive radiation and convergent evolut...
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Open AccessTranscriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby
The thymus plays a critical role in the development and maturation of T-cells. Humans have a single thoracic thymus and presence of a second thymus is considered an anomaly. However, many vertebrates have mult...
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Open AccessComparative and demographic analysis of orang-utan genomes
The genome of the Southeast Asian great ape or orang-utan has been sequenced — specifically a draft assembly of a Sumatran female individual and short-read sequence data from five further Sumatran and five Bor...
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Open AccessMolecular evolution of genes in avian genomes
Obtaining a draft genome sequence of the zebra finch (Taeniopygia guttata), the second bird genome to be sequenced, provides the necessary resource for whole-genome comparative analysis of gene sequence evolution...
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Open AccessThe genome of a songbird
The genome of the zebra finch — a songbird and a model for the study of vertebrate brain, behaviour and evolution — has been sequenced. Its comparison with the chicken genome, the only other bird genome availa...
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Erratum: Genome analysis of the platypus reveals unique signatures of evolution
Nature 453, 175–183 (2008) In this Article, Mikhail Nefedov and Pieter J. de Jong were omitted from the author list.
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Open AccessRapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammals
The draft mouse (Mus musculus) genome sequence revealed an unexpected proliferation of gene duplicates encoding a family of secretoglobin proteins including the androgen-binding protein (ABP) α, β and γ subunits....
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Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian (‘marsupial’) species to be sequenced, the opossum provides a unique persp...
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Genome sequence, comparative analysis and haplotype structure of the domestic dog
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest bec...
