7 Result(s)

Article

Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

Low-density lipoprotein receptor-related protein 1 (LRP1) regulates lipid and glucose metabolism in liver and adipose tissue. It is also involved in central nervous system regulation of food intake and leptin ...

Hua Mao, Pamela Lockyer, Luge Li, Christie M. Ballantyne… in Nature Communications (2017)

Article

HSP70-1 is required for interleukin-5-induced angiogenic responses through eNOS pathway

We report a pivotal role for IL-5 as an angiogenic activator. IL-5 increased proliferation, migration and colony tube formation in HUVECs associated with the phosphorylation of ERK and AKT/eNOS, and promoted m...

Sung Lyea Park, Tae-Wook Chung, Sangtae Kim, Byungdoo Hwang… in Scientific Reports (2017)

Article

CHIP^−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications

Genetic ablation of C-terminus of Hsc70-interacting protein (CHIP) E3 ubiquitin-ligase impairs hepatic cytochrome P450 CYP2E1 degradation. Consequent CYP2E1 gain of function accelerates reactive O₂ species (ROS) ...

Sung-Mi Kim, James P. Grenert, Cam Patterson, Maria Almira Correia in Scientific Reports (2016)

Article

Emerging evidence of coding mutations in the ubiquitin–proteasome system associated with cerebellar ataxias

Cerebellar ataxia (CA) is a disorder associated with impairments in balance, coordination, and gait caused by degeneration of the cerebellum. The mutations associated with CA affect functionally diverse genes;...

Sarah M Ronnebaum, Cam Patterson, Jonathan C Schisler in Human Genome Variation (2014)

Article

Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) is expressed in neuropeptide Y and proopiomelanocortin (POMC) neurons in the arcuate nucl...

Ji-Yao Li, Biaoxin Chai, Weizhen Zhang, **aobin Wu, Chao Zhang… in BMC Neuroscience (2011)

Article

A Good Idea: A Physician’s Perspective on Genetic Counseling for Hypertrophic Cardiomyopathy

Cam Patterson in Journal of Cardiovascular Translational Research (2009)

Article

Tobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males

Strong epidemiologic evidence correlates tobacco use with a variety of serious adverse health effects, but the biological mechanisms that produce these effects remain elusive.

Peter C Charles, Brian D Alder, Eleanor G Hilliard… in BMC Medical Genomics (2008)