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  1. Article

    Open Access

    Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase

    Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) play a central role in tryptophan metabolism and are involved in many cellular and disease processes. Here we report the crystal structure...

    Ariel Lewis-Ballester, Farhad Forouhar, Sung-Mi Kim, Scott Lew… in Scientific Reports (2016)

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  2. Article

    Open Access

    CHIP−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications

    Genetic ablation of C-terminus of Hsc70-interacting protein (CHIP) E3 ubiquitin-ligase impairs hepatic cytochrome P450 CYP2E1 degradation. Consequent CYP2E1 gain of function accelerates reactive O2 species (ROS) ...

    Sung-Mi Kim, James P. Grenert, Cam Patterson, Maria Almira Correia in Scientific Reports (2016)

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  3. No Access

    Chapter

    Inhibition of Cytochrome P450 Enzymes

    Maria Almira Correia, Paul R. Ortiz de Montellano in Cytochrome P450 (2005)

  4. No Access

    Chapter

    Inhibition of Cytochrome P450 Enzymes

    The catalytic cycle of cytochrome P450 (see Chapters 3 and 8) traverses three steps that are particularly vulnerable to inhibition: (1) the binding of substrates, (2) the binding of molecular oxygen subsequent...

    Paul R. Ortiz de Montellano, Maria Almira Correia in Cytochrome P450 (1995)