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  1. No Access

    Article

    Central and Peripheral Irisin Differentially Regulate Blood Pressure

    Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. Th...

    Weizhen Zhang, Lin Chang, Chao Zhang, Ruthann Zhang… in Cardiovascular Drugs and Therapy (2015)

  2. No Access

    Article

    TNFα Causes Thrombin-Dependent Vagal Neuron Apoptosis in Inflammatory Bowel Disease

    The role of peripheral tumor necrosis factor alpha (TNFα) in inflammatory bowel disease (IBD) is well established, but its central nervous system (CNS) effects are not understood. Thrombin, another mediator of...

    Danielle Fritze, Weizhen Zhang, Ji-Yao Li… in Journal of Gastrointestinal Surgery (2014)

  3. No Access

    Article

    Thrombin Mediates Vagal Apoptosis and Dysfunction in Inflammatory Bowel Disease

    In inflammatory bowel disease, autonomic dysfunction contributes to symptoms, morbidity, and health care resource utilization. Efferent vagal neurons, which provide the primary parasympathetic input to the gas...

    Danielle Fritze, Weizhen Zhang, Ji-Yao Li… in Journal of Gastrointestinal Surgery (2014)

  4. Article

    Open Access

    Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

    The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) is expressed in neuropeptide Y and proopiomelanocortin (POMC) neurons in the arcuate nucl...

    Ji-Yao Li, Biaoxin Chai, Weizhen Zhang, **aobin Wu, Chao Zhang… in BMC Neuroscience (2011)

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