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  1. No Access

    Article

    Untargeted metabolomics analysis of ischemia–reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats

    The effects of exercise on the heart and its resistance to disease are well-documented. Recent studies have identified that exercise-induced resistance to arrhythmia is due to the preservation of mitochondrial...

    Traci L. Parry, Joseph W. Starnes, Sara K. O’Neal, James R. Bain… in Metabolomics (2017)

  2. No Access

    Article

    Diggin′ on U(biquitin): A Novel Method for the Identification of Physiological E3 Ubiquitin Ligase Substrates

    The ubiquitin–proteasome system (UPS) plays a central role in maintaining protein homeostasis, emphasized by a myriad of diseases that are associated with altered UPS function such as cancer, muscle-wasting, a...

    Carrie E. Rubel, Jonathan C. Schisler, Eric D. Hamlett… in Cell Biochemistry and Biophysics (2013)

  3. No Access

    Article

    Breast cancer quality control

    Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cel...

    Cam Patterson, Sarah Ronnebaum in Nature Cell Biology (2009)

  4. No Access

    Article

    The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

    To maintain quality control in cells, mechanisms distinguish among improperly folded peptides, mature and functional proteins, and proteins to be targeted for degradation. The molecular chaperones, including h...

    Patrice Connell, Carol A. Ballinger, Jihong Jiang, Yaxu Wu… in Nature Cell Biology (2001)

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    Article

    The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

    The folding of both wild-type and mutant forms of the cystic-fibrosis transmembrane-conductance regulator (CFTR), a plasma-membrane chloride-ion channel, is inefficient1,2,3,4. Most nascent CFTR is retained in th...

    Geoffrey C. Meacham, Cam Patterson, Wenyue Zhang, J. Michael Younger… in Nature Cell Biology (2001)

  6. No Access

    Article

    Genomic structure of the human KDR/flk-1 gene

    Li-Yan Yin, Yaxu Wu, Carol A. Ballinger, Cam Patterson in Mammalian Genome (1998)