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  1. Article

    ß-endorphin induces general anaesthesia by an interaction with opiate receptors

    ß-endorphin, administered into the cerebral ventricles of rats, provokes a sequence of behavioural and electroencephalographic (EEG) responses similar to those observed with general anaesthetics used clinicall...

    V. Havlicek, F. S. LaBella, C. Pinsky… in Canadian Anaesthetists’ Society Journal (1980)

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  2. Article

    The effect of morphine on human neuromuscular transmission

    By utilizing high frequency nerve stimulation, we observed the effects of morphine sulphate, 0.5 mg kg-1 on human neuromuscular transmission. Tetanic fade at 50, 100 and 200 hz did not change during the one hour ...

    P. C. Duke, C. H. Johns, C. Pinsky, P. Goertzen in Canadian Anaesthetists’ Society Journal (1979)

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    Article

    Intraventricular Met5-enkephalin causes unexpected lowering of pain threshold and narcotic withdrawal signs in rats

    PEPTIDES with opiate properties have been demonstrated in brain1–3 and pituitary4–7. Goldstein8 has postulated that sustained low-intensity pain might promote the central mobilisation of endogenous opioid as part...

    L. LEYBIN, C. PINSKY, F. S. LABELLA, V. HAVLICEK, M. REZEK in Nature (1976)

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    Article

    Morphine Withdrawal Syndrome Responses to Cholinergic Antagonists and to a Partial Cholinergic Agonist

    MORPHINE impairs the release of acetylcholine (ACh) at muscarinic and nicotinic sites in the periphery1–3, and within the brain4–8. Paton9 suggested that morphine's ability to impair ACh release might be the orig...

    C. PINSKY, R. C. A. FREDERICKSON, A. J. VAZQUEZ in Nature (1973)

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    Article

    Effects of Morphine and its Antagonists on Release of Cerebral Cortical Acetylcholine

    SEVERAL, studies have shown that the narcotic analgesic morphine and morphine-like compounds reduce the release of acetylcholine (ACh) at peripheral cholinergic junctions1–3, but there is relatively little eviden...

    KHEM JHAMANDAS, C. PINSKY, J. W. PHILLIS in Nature (1970)

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    Article

    Evidence for a Postsynaptic Origin of the Surface-negative Response to Direct Stimulation of the Cat's Cerebral Cortex

    ADRIAN1 first demonstrated that a surface-negative potential, lasting approximately 20 msec, is produced by a single brief electrical stimulus of weak intensity applied to the exposed cerebral cortex. This respon...

    G. B. FRANK, C. PINSKY in Nature (1964)