57 Result(s)

Article

Serum sex hormone-binding globulin levels are reduced and inversely associated with intrahepatic lipid content and saturated fatty acid fraction in adult patients with glycogen storage disease type 1a

De novo lipogenesis has been inversely associated with serum sex hormone-binding globulin (SHBG) levels. However, the directionality of this association has remained uncertain. We, therefore, studied individua...

P. I. H. G. Simons, O. Valkenburg… in Journal of Endocrinological Investigation (2022)

Article

Association of physical activity and sedentary time with structural brain networks—The Maastricht Study

We assessed whether objectively measured low- and high-intensity physical activity (LPA and HPA) and sedentary time (ST) were associated with white matter connectivity, both throughout the whole brain and in b...

Laura W. M. Vergoossen, J. F. A. Jansen, J. J. A. de Jong… in GeroScience (2021)

Article

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

Hypoxia is prevalent in atherosclerotic plaques, promoting plaque aggravation and subsequent cardiovascular disease (CVD). Transmembrane protein carbonic anhydrase IX (CAIX) is hypoxia-induced and can be shed ...

J. A. F. Demandt, L. J. Dubois, K. van Kuijk, M. Zaťovičová, H. **… in Scientific Reports (2021)

Article

Bariatric surgery in adolescents: a prospective randomized controlled trial comparing laparoscopic gastric banding to combined lifestyle interventions in adolescents with severe obesity (BASIC trial)

Obesity in children and adolescents is an increasing problem associated with multiple co-morbidities including metabolic and endocrine changes, cardiovascular abnormalities, and impaired quality of life. Combi...

Y. G. M. Roebroek, G. F. Paulus, E. G. A. H. van Mil… in BMC Pediatrics (2019)

Article

The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with high-resolution peripheral quantitative computed tomography—The Maastricht Study

In this small cross-sectional study of predominantly well-treated participants with relatively short-term type 2 diabetes duration, HbA1c > 7% (53 mmol/mol) was associated with lower cortical density and thick...

E. A. C. de Waard, J. J. A. de Jong, A. Koster… in Osteoporosis International (2018)

Article

Alcohol and red wine consumption, but not fruit, vegetables, fish or dairy products, are associated with less endothelial dysfunction and less low-grade inflammation: the Hoorn Study

Endothelial dysfunction and low-grade inflammation are key phenomena in the pathobiology of cardiovascular disease (CVD). Their dietary modification might explain the observed reduction in CVD that has been as...

B. C. T. van Bussel, R. M. A. Henry, C. G. Schalkwijk… in European Journal of Nutrition (2018)

Article

Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study

Altered regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in type 1 diabetes. We invest...

S. A. Peeters, L. Engelen, J. Buijs, A. Jorsal, H.-H. Parving… in Cardiovascular Diabetology (2017)

Article

The association between glucose metabolism status, diabetes severity and a history of fractures and recent falls in participants of 50 years and older—the Maastricht Study

In this cohort of relatively young and well-treated participants with type 2 diabetes, we found no association between diabetes status and a history of previous fractures and recent falls. Furthermore, no asso...

E. A. C. de Waard, A. Koster, T. Melai, T. A. van Geel… in Osteoporosis International (2016)

Article

Excess Cardiovascular Risk in Diabetic Women: A Case for Intensive Treatment

Diabetes is a common and rapidly growing disease that affects more than 380 million people worldwide and is an established risk factor for cardiovascular disease with differential effects on women compared to ...

C. Recarti, S. J. S. Sep, C. D. A. Stehouwer, T. Unger in Current Hypertension Reports (2015)

Article

Pulse pressure measured at the level of the femoral artery, but not at the level of the aorta, carotid and brachial arteries, is associated with the incidence of coronary heart disease events in a population with a high prevalence of type 2 diabetes and impaired glucose metabolism — The Hoorn study

Central (aortic or carotid) pulse pressure (PP) is more strongly associated with local organ damage and possibly mortality than brachial PP.

A. D. Protogerou, T. T. van Sloten, R. M. A. Henry, J. M. Dekker… in Artery Research (2015)

Article

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

Methylglyoxal (MGO) is a major precursor for advanced glycation end-products (AGEs), which are thought to play a role in vascular complications in diabetes. Known MGO-arginine-derived AGEs are 5-hydro-5-methyl...

M. G. A. van Eupen, M. T. Schram, H. M. Colhoun, N. M. J. Hanssen… in Diabetologia (2013)

Article

Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: the USE-IMT initiative

The aim of this work was to investigate whether measurement of the mean common carotid intima-media thickness (CIMT) improves cardiovascular risk prediction in individuals with diabetes.

H. M. den Ruijter, S. A. E. Peters, K. A. Groenewegen, T. J. Anderson… in Diabetologia (2013)

Article

Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates. The Hoorn Study

Proinsulin is possibly associated with cancer through activation of insulin receptor isoform A. We sought to investigate the associations between proinsulin and 20 year cancer mortality rates.

I. Walraven, E. van ’t Riet, C. D. A. Stehouwer, B. C. P. Polak, A. C. Moll… in Diabetologia (2013)

Article

1.1 Reference Intervals for Carotid Stiffness

Non-invasive measures of common carotid artery properties, such as diameter, distension and local pulse pressure, have been widely used to determine carotid stiffness (CS), which is associated with cardiovascu...

L. Engelen, I. Ferreira, C. D. A. Stehouwer, S. Laurent, P. Boutouyrie in Artery Research (2012)

Article

Higher plasma high-mobility group box 1 levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12 year follow-up study

This study aimed to investigate the associations of plasma levels of the pro-inflammatory cytokine high-mobility group box 1 (HMGB1) with incident cardiovascular disease (CVD) and all-cause mortality in patien...

J. W. M. Nin, I. Ferreira, C. G. Schalkwijk, A. Jorsal, M. H. Prins… in Diabetologia (2012)

Article

Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients

The present study compares the impact of endurance- vs resistance-type exercise on subsequent 24 h blood glucose homeostasis in individuals with impaired glucose tolerance (IGT) and type 2 diabetes.

J.-W. van Dijk, R. J. F. Manders, K. Tummers, A. G. Bonomi… in Diabetologia (2012)

Article

Complement C3: an emerging risk factor in cardiometabolic disease

C3 is the central component of the complement system and activation of C3 via any of the three major activation pathways—the classical, the lectin and the alternative pathways—results in initiation of the term...

E. Hertle, M. M. J. van Greevenbroek, C. D. A. Stehouwer in Diabetologia (2012)

Article

5.4: Lifetime Adherence to A Mediterranean Diet (MD) Pattern is Associated with Lower Carotid Stiffness in Young Adults: The Amsterdam Growth and Health Longitudinal Study

To investigate whether lifetime adherence to an MD pattern (i.e., from adolescence to adulthood) is associated with arterial stiffness in adults.

R. J. J. M. van de Laar, C. D. A. Stehouwer, B. C. T. van Bussel… in Artery Research (2011)

Article

P8.01: Endothelial Dysfunction and Low-Grade Inflammation are Associated with Arterial Stiffness in Healthy Adults Over A 6-Year Period the Amsterdam Growth and Health Longitudinal Study (AGAHLS)

Endothelial dysfunction and low-grade inflammation are associated with cardiovascular disease. Arterial stiffening plays an important role in cardiovascular disease and thus may be a mechanism through which en...

B. C. T. van Bussel, F. Schouten, R. M. A. Henry, C. G. Schalkwijk… in Artery Research (2011)

Article

Risk scores for predicting type 2 diabetes: using the optimal tool

M. Alssema, D. Vistisen, M. W. Heymans, G. Nijpels, C. Glümer, P. Z. Zimmet… in Diabetologia (2011)