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Article
Open AccessThe role of receptor MAS in microglia-driven retinal vascular development
The receptor MAS, encoded by Mas1, is expressed in microglia and its activation has been linked to anti-inflammatory actions. However, microglia are involved in several different processes in the central nervous ...
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Article
Open AccessExcess Cardiovascular Risk in Diabetic Women: A Case for Intensive Treatment
Diabetes is a common and rapidly growing disease that affects more than 380 million people worldwide and is an established risk factor for cardiovascular disease with differential effects on women compared to ...
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Article
Molekulargenetische und molekularpathologische Analysen
Molekulare Analysen gewinnen kontinuierlich an Bedeutung für individualisierte Therapien, insbesondere in der Onkologie. Der vorliegende Beitrag gibt einen Überblick über molekulargenetische und molekularpatho...
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Article
Open AccessNo Generation, Blood Pressure and Vascular Stiffness: Lessons from the Angiotensin AT2 Receptor
Vascular remodeling participates in the development and progression of cardiovascular conditions such as hypertension, atherosclerosis or aneurysm. This process is fine-tuned by neuro-humoral regulatory pathwa...
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Article
Zuverlässigkeit notärztlicher Verdachtsdiagnosen
Die Prognose Schwerverletzter wird von der präklinischen Versorgung mitbestimmt. Der notärztlichen Einschätzung des Verletzungsschweregrads kommt dabei eine Schlüsselposition zu, da diese maßgeblich Art und Um...
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Article
P4.21: Mild Uremia Induces Aortic Dilatation and Heart Remodelling Via Nf-Kb Activation
The aim of this study was to investigate the effects of mild uremia on aortic and heart remodelling in the rat.
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Article
Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia
In subjects with schizophrenia, impairments in working memory are associated with dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to be due, at least in part, to abnormaliti...
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Article
Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood
Brain-derived neurotrophic factor (BDNF) has been reported to be critical for the development of cortical inhibitory neurons. However, the effect of BDNF on the expression of transcripts whose protein products...
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Article
Vascular protection in diabetes: a pharmacological view of angiotensin II type 1 receptor blockers
Vascular protection is key to reducing the morbidity associated with diabetes. Angiotensin II is known to exert a variety of deleterious effects on the vasculature, and this is likely to be a major explanation...
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Article
Recognition and management of overweight and obesity in primary care in Germany
BACKGROUND: In contrast to the well-documented high prevalence of overweight and obesity in the general population, the prevalence, recognition rates and management by primary care physicians—as the core gatekeep...
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Article
Patterns of antihypertensive drug utilization in primary care
In the treatment of hypertension, physicians’ attitudes and practice patterns are receiving increased attention as contributors to poor blood pressure (BP) control. Thus, current use of antihypertensive drugs ...
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Chapter
Therapie der essenziellen Hypertonie
Es ist unstrittig, dass lebensstiländernde Maßnahmen den erhöhten Blutdruck erheblich senken und vor allen Dingen in ihrer Komplexität unter Verwendung verschiedener Strategien den Effekt einer medikamentösen ...
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Chapter
Pathophysiologische Faktoren
Arzneimittelinduzierte Hypertonien, die zu den sekundären Bluthockdruckformen gezählt werden, sind durchaus nicht selten. Eine Vielzahl von Medikamenten und (chemischen) Substanzen kann transiente oder auch da...
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Chapter
AT2 Function and Target Genes
Angiotensin II (ANG II), the biologically active component of renin-angiotensin system (RAS), acts through two receptor subtypes, the AT1 and the AT2 receptors. All classic physiological effects of ANG II, such a...
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Article
The hermitian level of composition algebras
The hermitian level of composition algebras with involution over a ring is studied. In particular, it is shown that the hermitian level of a composition algebra with standard involution over a semilocal ring,...
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Article
The renin-angiotensin system in the brain: possible therapeutic implications for AT1-receptor blockers
Biochemical, physiological and functional studies suggest that the brain renin-angiotensin system (RAS) is regulated independently of the peripheral RAS. The classical actions of angiotensin II in the brain in...
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Article
Peripherally applied candesartan inhibits central responses to angiotensin II in conscious rats
In the brain, angiotensin II (Ang II) induces various effects such as blood pressure increase, the release of arginine vasopressin (AVP) and drinking behaviour. In the present study, we investigated the abili...
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Chapter and Conference Paper
The Cardiovascular Continuum — Pathophysiology and Targets for Therapy
It has become widely acknowledged that heart failure can no longer be regarded simply as a discrete clinical entity, but rather as the endpoint of a continuum of cardiovascular disease [1, 2]. Research conduct...
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Article
Blocking the tissue renin-angiotensin system: the future cornerstone of therapy
The development of angiotensin-converting enzyme inhibitors and selective angiotensin type 1 (AT1)- receptor antagonists has provided new insights into understanding the mechanism of the renin-angiotensin system ...
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Article
Electricity and emission-permits trade as a means of curbing CO2 emissions in the Nordic countries
The four Nordic countries Sweden, Denmark, Finland and Norway have fully integrated electricity grids, implying that electricity trade hitherto has accounted for a crucial part of each country’s power balance....
