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Article
Open AccessPlasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study
Altered regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in type 1 diabetes. We invest...
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Article
Open AccessHigher plasma high-mobility group box 1 levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12 year follow-up study
This study aimed to investigate the associations of plasma levels of the pro-inflammatory cytokine high-mobility group box 1 (HMGB1) with incident cardiovascular disease (CVD) and all-cause mortality in patien...
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Article
Open AccessP11.03 Pulse Pressure Partially Explains the Increased Incident Cardiovascular Disease Associated with Inflammation in Type 1 Diabetes: A 12-Yr Follow-Up Study
To investigate, in a prospective cohort of individuals with type 1 diabetes: 1) the association between an aggregated z-score of low-grade inflammation markers (CRP, IL-6, sPLA2 and sICAM-1) and pulse pressure...
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Article
Telomere length predicts all-cause mortality in patients with type 1 diabetes
Type 1 diabetic patients with diabetic nephropathy have increased mortality and morbidity compared with normoalbuminuric patients. Telomere length in proliferative cells is inversely related to the total numbe...
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Article
The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes
Hyperglycaemia increases oxidative stress and may thereby increase the risk of diabetic complications, including diabetic nephropathy. Cells are protected from oxidative damage by, for example, the manganese s...
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Article
Plasma osteoprotegerin levels predict cardiovascular and all-cause mortality and deterioration of kidney function in type 1 diabetic patients with nephropathy
The bone-related peptide osteoprotegerin is produced by vascular cells and is involved in the process of vascular calcification. The aim of this study was to investigate the predictive value of plasma levels o...
