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  1. Article

    Open Access

    Integrated molecular and multiparametric MRI map** of high-grade glioma identifies regional biologic signatures

    Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis...

    Leland S. Hu, Fulvio D’Angelo, Taylor M. Weiskittel… in Nature Communications (2023)

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    Physical Principles of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MRI

    The use of dynamic contrast-agent-enhanced magnetic resonance imaging (MRI) can provide insight into hemodynamic processes not detectable using conventional contrast-enhanced magnetic resonance (MR) techniques...

    Mark S. Shiroishi, Jerrold L. Boxerman, C. Chad Quarles… in Functional Neuroradiology (2023)

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    Article

    Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model

    The identification and targeting of biomarkers specific to prostate cancer (PCa) could improve its detection. Given the high expression of translocator protein (TSPO) in PCa, we investigated the use of [18F]VUIIS...

    Mohammed N. Tantawy, H. Charles Manning, Todd E. Peterson… in Molecular Imaging and Biology (2018)

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    Article

    In vivo neuroimaging and behavioral correlates in a rat model of chemotherapy-induced cognitive dysfunction

    Adjuvant chemotherapy has been used for decades to treat cancer, and it is well known that disruptions in cognitive function and memory are common chemotherapeutic adverse effects. However, studies using neuro...

    Robert L. Barry, Nellie E. Byun, M. Noor Tantawy… in Brain Imaging and Behavior (2018)

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    Article

    Quantitative [18F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+ Breast Cancer

    Evaluation of [18F]fluoromisonidazole ([18F]FMISO)-positron emission tomography (PET) imaging as a metric for evaluating early response to trastuzumab therapy with histological validation in a murine model of HER...

    Anna G. Sorace, Anum K. Syed, Stephanie L. Barnes… in Molecular Imaging and Biology (2017)

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    Article

    Trastuzumab improves tumor perfusion and vascular delivery of cytotoxic therapy in a murine model of HER2+ breast cancer: preliminary results

    To employ in vivo imaging and histological techniques to identify and quantify vascular changes early in the course of treatment with trastuzumab in a murine model of HER2+ breast cancer. Dynamic contrast-enha...

    Anna G. Sorace, C. Chad Quarles… in Breast Cancer Research and Treatment (2016)

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    Article

    Quantitative multimodality imaging in cancer research and therapy

    Recent advances in multimodality imaging in cancer have involved the integration of multiple quantitative, functional measurements that provide a more-comprehensive characterization of tumours. In this Review,...

    Thomas E. Yankeelov, Richard G. Abramson… in Nature Reviews Clinical Oncology (2014)