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Chapter and Conference Paper
Adriamycin Used in Combination with Conventional Agents in the Treatment of Solid Tumors
Among the effective agents recently introduced in cancer chemotherapy, the antibiotic adriamycin (ADM) has been shown to play an almost unique role in the treatment of neoplastic diseases. In its initial clini...
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Article
Un algoritmo di classificazione gerarchica
In questo lavoro viene illustrato un algoritmo di classificazione gerarchica di tipo agglomerativo (della famiglia cioè di quelli di Johnson) e vengono formulate alcune ipotesi riguardo al problema della selez...
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Chapter
Adjuvant Chemotherapy With Nitrosourea Compounds Following Surgery Plus Radiotherapy in Glioblastoma Multiforme
The outlook for patients with glioblastoma multiforme is almost uniformly fatal. Patients with this highly malignant tumor usually survive 2–4 months from the time of diagnosis with no intervention. Glioblasto...
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Chapter
Multimodal Therapy with CMF in Resectable Breast Cancer with Positive Axillary Nodes: The Milan Institute Experience
During the past few years, we have systematically published the short-term and the intermediate analysis of prospective randomized studies [4, 6, 15] with adjuvant combination chemotherapy in operable breast c...
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Chapter
Prospects for Doxorubicin in Adjuvant Breast Cancer Trials
More than a decade ago, our medical oncology team initiated the first clinical studies on doxorubicin (1, 2) and, within the group of solid tumors, breast cancer appeared to be one of the most responsive neopl...
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Chapter
Adjuvant Programs for Postmenopausal Women with Node-Positive Breast Cancer:Preliminary Analysis of 5-Year Results
The results of the first CMF program (cyclophosphamide, methotrexate, and fluorouracil given for 12 monthly cycles) indicated only a slight benefit for the subgroup of postmenopausal patients with node-positiv...
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Chapter
Relationship Between Estrogen Receptors and CMF Adjuvant Chemotherapy
The presence of estrogen receptors (ER) has been found to have prognostic significance in patients with resectable breast cancer, regardless of whether axillary nodes are positive or negative [12, 14]. Since a...
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Chapter
Validation (Test Set) of a Method for Detecting Associated Heart Conditions in LBBB by Means of BSM
We recently reported (1) a procedure for detecting associated heart condition(s) in left bundle branch block (LBBB), based on a multivariate analysis (Fisher’s discriminant analysis (2) of 10 voltage related v...
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Chapter and Conference Paper
Salvage Treatments in Relapsing Resectable Breast Cancer
There is convincing evidence that the natural history of resectable breast cancer can be perturbed by adjuvant medical intervention. In fact, a highly significant reduction in the recurrence rate has been docu...
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Chapter and Conference Paper
The Milan Experience with Adjuvant Chemotherapy in Premenopausal Breast Cancer
In spite of the many scientific and clinical debates which have involved adjuvant chemotherapy for high-risk resectable breast cancer, there is general agreement that polydrug regimens, in particular, CMF (cyc...
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Chapter
Chemotherapy of Advanced Disease
During the past 15 years, the potential of cytotoxic agents to palliate, or even cure in a few instances, metastatic breast cancer has undoubtedly reached a plateau. Despite innumerable reports dealing with pr...
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Chapter and Conference Paper
Changes in Left Ventricular Ejection Fraction During Arterial REM Sleep Desaturation and Exercise in Chronic Obstructive Pulmonary Disease and Sleep Apnea Syndrome
Exercise and rapid eye movement (REM) sleep are two important states during which oxyhemoglobin desaturation may occur in chronic obstructive pulmonary disease (COPD) [1, 2]. Sleep apnea also leads to oxygen d...
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Article
Cefuroxime and cefuroxime axetil versus amoxicillin plus clavulanic acid in the treatment of lower respiratory tract infections
In a large multinational study, the clinical and bacteriological efficacy of intravenous cefuroxime 750 mg t.i.d. followed by oral cefuroxime axetil 500 mg b.i.d. was compared to that of amoxicillin plus clavu...
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Chapter and Conference Paper
Primary Chemotherapy for Resectable Breast Cancer
Primary (neoadjuvant, preoperative) chemotherapy for surgically curative breast cancer is a novel treatment approach. The sequentially combined strategy derives from prior experience achieved with locally adva...
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Article
Central airway stenoses: preliminary results of spiral-CT-generated virtual bronchoscopy simulations in 29 patients
The purpose of this study was to determine the feasibility of using virtual bronchoscopy simulations to depict stenoses of the tracheobronchial tree. Virtual bronchoscopy simulations, based on ray casting, we...
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Article
A retrospective evaluation of HLA-A, B and -DRB1 matching in liver transplantation
Studies on the influence of histocompatibility in liver transplantation have not produced clear-cut results. We retrospectively studied the influence of HLA-A, B and -DRB1 matching on the survival of 517 live...
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Article
Endovascular treatment of superior vena cava obstruction in patients with malignancies
The aim of this study was to report our experience on the management of superior vena cava obstruction (SVCO) secondary to malignant disease, using endovascular procedures. Twenty-six patients with SVCO due t...
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Article
Phase I/II study of gemcitabine in association with vinorelbine for metastatic breast cancer
Background. Gemcitabine (G) and vinorelbine (V) have favorable safety profile and antitumor activity in metastatic breast cancer. To exploit their different mechanism of action and lack of overlap** toxicity, ...
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Chapter and Conference Paper
Content-Based Classification of Digital Photos
Annotating images with a description of the content can facilitate the organization, storage and retrieval of image databases. It can also be useful in processing images, by taking into account the scene depic...
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Article
Open AccessDifferential expression of telomerase reverse transcriptase (hTERT) in lung tumours
Human telomerase reverse transcriptase is a ribonucleoprotein that synthesises telomeric sequences, which decrease at each cell division. In cancer cells, its activity is linked to telomere maintenance leading...
