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Article
E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35
The transcription factor E2F1 has a key function during S phase progression and apoptosis. It has been well-demonstrated that the apoptotic function of E2F1 involves its ability to transactivate pro-apoptotic ...
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Article
E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIPshort
E2F1 is a transcription factor that plays a well-documented role during S phase progression and apoptosis. We had previously postulated that the low level of E2F1 in primary lung adenocarcinoma contributes to ...
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Article
Open AccessFunctional serotonin 5–HTTLPR polymorphism is a risk factor for migraine with aura
In the present work, we report that the functional serotonin transporter gene promoter (5–HTTLPR) polymorphism is involved in migraine pathogenesis. The distribution of 5–HTTLPR genotypes was significantly dif...
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Article
Open AccessDifferential expression of telomerase reverse transcriptase (hTERT) in lung tumours
Human telomerase reverse transcriptase is a ribonucleoprotein that synthesises telomeric sequences, which decrease at each cell division. In cancer cells, its activity is linked to telomere maintenance leading...