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Article
The preventive effect of Mori Ramulus on oxidative stress-induced cellular damage in skeletal L6 myoblasts through Nrf2-mediated activation of HO-1
The aim of the present study is to investigate the preventive effect of water extract of Mori Ramulus (MRWE) on oxidative stress-mediated cellular damages in rat skeletal L6 myoblasts. Our results demonstrated th...
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Article
Open AccessGold nanoparticle clusters for the investigation of therapeutic efficiency against prostate cancer under near-infrared irradiation
Gold particles have been widely used in the treatment of prostate cancer due to their unique optical properties, such as their light-heat conversion in response to near-infrared radiation. Due to well-defined ...
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Article
Open AccessDNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations
DNA damage is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, relationships between DNA damage accumulation, DNA damage response (DDR), and upper and lower motor neuron vulnerab...
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Article
Open AccessInhibition of Adipocyte Differentiation by Anthocyanins Isolated from the Fruit of Vitis coignetiae Pulliat is Associated with the Activation of AMPK Signaling Pathway
Anthocyanins are naturally occurring water-soluble polyphenolic pigments in plants that have been shown to protect against cardiovascular diseases, and certain cancers, as well as other chronic human disorders...
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Article
Geostatistical techniques to evaluate groundwater contamination and its sources in Miryang City, Korea
Miryang City has high seasonal variations in precipitation and small number of surface reservoirs. It uses much groundwater for living and irrigation purposes. This study delineates the characteristics and the...
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Article
Open AccessEthanol extract of Prunus mume fruit attenuates hydrogen peroxide-induced oxidative stress and apoptosis involving Nrf2/HO-l activation in C2C12 myoblasts
The fruit of the Prunus mume (Siebold) Siebold & Zucc, Rosaceae (Korean name: Maesil) has long been used as a health food or valuable medicinal material in traditional herb medicine in Southeast Asian countries. ...
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Article
Study on tank shape for sloshing assessment of LNG vessels under unrestricted filling operation
Conventional liquefied natural gas (LNG) vessels with membrane cargo containment systems have tank filling restrictions from 0.10 to 0.70 H (with H the internal tank height). The main reason for such restricti...
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Article
Widdrol-induced lipolysis is mediated by PKC and MEK/ERK in 3T3-L1 adipocytes
Obesity is a serious medical condition causing various diseases such as heart disease, type-2 diabetes, and cancer. Fat cells (adipocytes) play an important role in the generation of energy through hydrolysis ...
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Article
Open AccessFucoidan induces G1 arrest of the cell cycle in EJ human bladder cancer cells through down-regulation of pRB phosphorylation
Fucoidan, a sulfated polysaccharide found in marine algae and brown seaweeds, has been shown to inhibit the in vitro growth of human cancer cells. This study was conducted in cultured human bladder cancer EJ cell...
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Article
Enhanced autotrophic astaxanthin production from Haematococcus pluvialis under high temperature via heat stress-driven Haber–Weiss reaction
High temperatures (30–36 °C) inhibited astaxanthin accumulation in Haematococcus pluvialis under photoautotrophic conditions. The depression of carotenogenesis was primarily attributed to excess intracellular les...
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Article
Juniperus chinensis and the functional compounds, cedrol and widdrol, ameliorate α-melanocyte stimulating hormone-induced melanin formation in B16F10 cells
Anti-melanogenic activities of Juniperus chinensis methanol extracts (JCM) and isolation of functional compounds were investigated. JCM possessed potent anti-oxidative and tyrosinase inhibitory activities. α-Mela...
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Article
Open AccessSargassum horneri methanol extract rescues C2C12 murine skeletal muscle cells from oxidative stress-induced cytotoxicity through Nrf2-mediated upregulation of heme oxygenase-1
Sargassum horneri, an edible marine brown alga, is typically distributed along the coastal seas of Korea and Japan. Although several studies have demonstrated the anti-oxidative activity of this alga, the regulat...
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Article
Open AccessEssential oils purified from Schisandrae semen inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 activation and migration of human aortic smooth muscle cells
The migration of vascular smooth muscle cells from the tunica media to the subendothelial region may be a key event in the development of atherosclerosis after arterial injury. In this study, we investigated t...
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Article
TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the develo** brain
Intracellular Ca2+ signal is a key regulator of axonal growth during brain development. As transient receptor potential (TRP) channels are permeable to Ca2+ and mediate numerous brain functions, it is conceivable...
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Article
Effects of unripe apple polyphenols on the expression of matrix metalloproteinase-1 and type-1 procollagen in ultraviolet irradiated human skin fibroblasts
Bioassay-guided isolation of an aqueous ethanolic extract from the unripe fruits of Malus pumila cv. Fuji using matrix metalloproteinase-1 (MMP-1) inhibition and type-1 procollagen inducing assays led to isolatio...
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Article
Angiotensin converting enzyme inhibitory benzopyranoids from Angelica gigas
Angiotensin converting enzyme (ACE) plays a major role in the regulation of blood pressure. The potential antihypertensive activity of Angelica gigas was evaluated in vitro by its ability to inhibit ACE. A methan...
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Article
Gene expression and characterization of thermostable glutamate decarboxylase from Pyrococcus furiosus
Gene encoding for a putative glutamate decarboxylase (GAD: EC 4.1.1.15) from the hyperthermophilic archaeon Pyrococcus furiosus was cloned and the biochemical characteristics of the resulting recombinant protein ...
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Article
Identification of the first archaeal arylsulfatase from Pyrococcus furiosus and its application to desulfatation of agar
A gene encoding a putative arylsulfatase from the hyperthermophilic archaeon Pyrococcus furiosus was identified, cloned, and expressed as a fusion protein with a Sce VMA intein and chitin binding domain (CBD) res...
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Article
Combined analyses of chemometrics and kriging for identifying groundwater contamination sources and origins at the Masan coastal area in Korea
Hydrogeochemical analyses including the basic statistics of chemical components, Piper’s trilinear diagram, and Mazor’s compositional bivariate diagram revealed that the main source and origin of groundwater c...
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Article
Natural rubber/fluoroelastomer blended composites using colloid stabilization-destabilization method
The fluoroelastomer rubber (FR) was successfully incorporated in natural rubber (NR) matrix composites using a colloid stabilization-destabilization methodology in the spherical shape of a few-micrometer size,...
