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Article
Open AccessA secreted form of chorismate mutase (Rv1885c) in Mycobacterium bovis BCG contributes to pathogenesis by inhibiting mitochondria-mediated apoptotic cell death of macrophages
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), and its pathogenicity is associated with its ability to evade the host defense system. The secretory form of the chorismate mutase of M. tub...
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Article
A study on the thermal aging characteristics of an electro-osmotic pump using a liquid crystal polymer as a packaging material
The generation of bubbles due to the poor barrier property of packaging materials with regard to gas or water permeability can be detrimental to the performance and stability of electro-osmotic (EO) pumps, as ...
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Article
Open AccessThe moderating effect of prefrontal response to sleep-related stimuli on the association between depression and sleep disturbance in insomnia disorder
We investigated differences in brain activity in response to sleep-related pictures between chronic insomnia disorder (CID) patients and good sleepers (GS), and examined whether brain activity moderated the re...
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Article
COVID-19 vaccine development based on recombinant viral and bacterial vector systems: combinatorial effect of adaptive and trained immunity
Severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2) infection, which causes coronavirus disease 2019 (COVID-19), has led to many cases and deaths worldwide. Therefore, a number of vaccine candid...
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Article
Open AccessNorepinephrine modulates IL-1β-induced catabolic response of human chondrocytes
The influence of the sympathetic nervous system (SNS) on metabolism of bone and cartilage expressing β-adrenergic receptors (AR) was suggested. Here, we investigated whether the SNS functions as a modulator of...
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Article
Open AccessMultitask fMRI and machine learning approach improve prediction of differential brain activity pattern in patients with insomnia disorder
We investigated the differential spatial covariance pattern of blood oxygen level-dependent (BOLD) responses to single-task and multitask functional magnetic resonance imaging (fMRI) between patients with psyc...
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Article
Open AccessThe TLR-2/TonEBP signaling pathway regulates 29-kDa fibronectin fragment-dependent expression of matrix metalloproteinases
Tonicity-responsive enhancer-binding protein (TonEBP; nuclear factor of activated T cells 5) is a transcription factor that responds to changes in osmolality. However, recent studies have shown that it also mo...
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Article
Feasibility study of a non-destructive assay system for certifying identified isotopes and their activity concentrations for radioactive waste in a large container
We have generated a system concept for a non-destructive assay (NDA) system to certify identified isotopes and their activity concentrations for radioactive waste in a large container. Various optimization stu...
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Article
Trends in prescriptions for sedative–hypnotics among Korean adults: a nationwide prescription database study for 2011–2015
This study investigated prescriptions for sedative–hypnotics via data obtained from the Health Insurance Review and Assessment (HIRA) service.
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Article
Open AccessMicroRNA-365 regulates IL-1β-induced catabolic factor expression by targeting HIF-2α in primary chondrocytes
Endothelial Per-Arnt-Sim domain protein-1/hypoxia-inducible factor-2α (EPAS-1/ HIF-2α) is a catabolic transcription factor that regulates osteoarthritis (OA)-related cartilage destruction. Here, we examined wh...
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Article
Effect of potassium addition on bimetallic PtSn/θ-Al2O3 catalyst for dehydrogenation of propane to propylene
PtSn/θ-Al2O3 catalysts with different amounts of K (0.14, 0.22, 0.49, 0.72, and 0.96 wt%) are prepared to investigate the K effects on the PtSn catalyst in propane dehydrogenation (PDH). KPtSn catalyst with 0.xx ...
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Article
Open AccessFibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes
Fibronectin fragments (FN-fs) are increased in the cartilage of patients with osteoarthritis (OA) and have a potent chondrolytic effect. However, little is known about the cellular receptors and signaling mech...
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Article
TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the develo** brain
Intracellular Ca2+ signal is a key regulator of axonal growth during brain development. As transient receptor potential (TRP) channels are permeable to Ca2+ and mediate numerous brain functions, it is conceivable...
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Article
Disseminated congenital tuberculosis presenting as peritonitis in an infant
Congenital tuberculosis is a rare disease which is curable after early diagnosis. Making an early diagnosis of tuberculosis in an infant is difficult, however, because of its nonspecific clinical findings. It ...
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Article
Open AccessPlatinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis
Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect ag...
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Protocol
Analysis of a Transcription Factor Using Transient Assay in Arabidopsis Protoplasts
Regulation of gene expression by transcription factors is a fundamental mechanism in essentially all aspects of cellular processes. Transient expression assay of a reporter plasmid containing a reporter gene d...
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Article
Characterization of SHORT-ROOT function in the Arabidopsis root vascular system
Development of the vascular tissues is a dynamic process that integrates extrinsic and intrinsic factors to control vascular tissue formation throughout the plant life cycle. During vascular tissue formation in A...
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Article
Leukemic glaucoma in a patient with chronic myeloid leukemia treated by intracameral methotrexate
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Article
Overexpression and Inactivation of UGT73B2 Modulate Tolerance to Oxidative Stress in Arabidopsis
Glycosyltransferases (GTs) play an important role in modulating solubility, stability, bioavailability, and bioactivity of secondary metabolites, such as flavonoids. In Arabidopsis thaliana, at least 120 family 1...
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Article
Large-scale analysis of the GRAS gene family in Arabidopsis thaliana
GRAS proteins belong to a plant-specific transcription factor family. Currently, 33 GRAS members including a putative expressed pseudogene have been identified in the Arabidopsis genome. With a reverse genetic ap...
