14 Result(s)

Article

Tripartite motif containing 26 prevents steatohepatitis progression by suppressing C/EBPδ signalling activation

Currently potential preclinical drugs for the treatment of nonalcoholic steatohepatitis (NASH) and NASH-related pathopoiesis have failed to achieve expected therapeutic efficacy due to the complexity of the pa...

Minxuan Xu, Jun Tan, **n Liu, Li Han, Chenxu Ge, Yujie Zhang… in Nature Communications (2023)

Article

Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK

Nonalcoholic steatohepatitis (NASH), a common clinical disease, is becoming a leading cause of hepatocellular carcinoma (HCC). Dual specificity phosphatase 22 (DUSP22, also known as JKAP or JSP-1) expressed in...

Chenxu Ge, Jun Tan, **anling Dai, Qin Kuang, Shaoyu Zhong… in Nature Communications (2022)

Article

Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl

Dendrobium nobile Lindl. has been used as a traditional Chinese medicine for a long time, in which the most important compound is dendrobine functioning in a variety of pharmacological activities. Farnesyl diphos...

Daoyong Gong, Bin Wu, Hongting Qin, Dezhao Fu, Shunxing Guo, Bochu Wang… in AMB Express (2022)

Article

The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes

Systemic metabolic syndrome significantly increases the risk of morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). However, no effectiv...

Minxuan Xu, Jun Tan, Wei Dong, Benkui Zou, Xuepeng Teng… in Nature Communications (2022)

Article

Keratin-A6ACA NPs for gastric ulcer diagnosis and repair

Yi Ding, Run Meng, Haimeng Yin, Zongkun Hou… in Journal of Materials Science: Materials in… (2021)

Article

Future perspective: high-throughput construction of new ultrasensitive cytokine and virion liquid chips for high-throughput screening (HTS) of anti-inflammatory drugs or clinical diagnosis and treatment of inflammatory diseases

Pathogen–host cell interactions play an important role in many human infectious and inflammatory diseases. Several pathogens, including Escherichia coli (E. coli), Mycobacterium tuberculosis (M. tb), and even the...

Yingzhu Feng, Jiuhong Huang, Chuanhua Qu… in Analytical and Bioanalytical Chemistry (2020)

Article

Establishment of an Experimental Intracerebral Haemorrhage Model for Mass Effect Research using a Thermo-sensitive Hydrogel

The mechanical response of brain tissue closely relates to cerebral blood flow and brain diseases. During intracerebral haemorrhage (ICH), a mass effect occurs during the initial bleeding and results in signif...

Yuhua Gong, Yu** Gong, Zongkun Hou, Tingwang Guo, Jia Deng… in Scientific Reports (2019)

Article

Neural Injuries Induced by Hydrostatic Pressure Associated With Mass Effect after Intracerebral Hemorrhage

Mass effect induced by growing hematoma is one of the mechanisms by which intracerebral hemorrhage (ICH) may result in brain injuries. Our goal was to investigate the damage mechanism of hydrostatic pressure a...

Tingwang Guo, Peng Ren, **aofei Li, Tiantian Luo, Yuhua Gong… in Scientific Reports (2018)

Article

Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release

Nanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms delivery depending on the mucoadhesive interaction, and keratin has been applied for biomedical applications ...

Zhongjun Cheng, **aoliang Chen, Dongliang Zhai, Feiyan Gao… in Journal of Nanobiotechnology (2018)

Article

Discovery of tauroursodeoxycholic acid biotransformation enzymes from the gut microbiome of black bears using metagenomics

Tauroursodeoxycholic acid (TUDCA) has been used to treat many diseases effectively. 7α-hydroxysteroid dehydrogenase (7α-HSDH) and 7β-hydroxysteroid dehydrogenase (7β-HSDH) are two key enzymes that drive the ef...

Can Song, Bochu Wang, Jun Tan, Liancai Zhu, Deshuai Lou in Scientific Reports (2017)

Article

Effects of nitrogen availability on polymalic acid biosynthesis in the yeast-like fungus Aureobasidium pullulans

Polymalic acid (PMA) is a novel polyester polymer that has been broadly used in the medical and food industries. Its monomer, L-malic acid, is also a potential C4 platform chemical. However, little is known ab...

Yongkang Wang, **aodan Song, Yongjun Zhang, Bochu Wang… in Microbial Cell Factories (2016)

Article

The three-dimensional structure of Clostridium absonum 7α-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition

7α-hydroxysteroid dehydrogenase (7α-HSDH) can catalyse the oxidation of C7 α-OH of the steroid nucleus in the bile acid metabolism. In the paper we determined the crystal structure of 7α-HSDH from Clostridium abs...

Deshuai Lou, Bochu Wang, Jun Tan, Liancai Zhu, **aoxi Cen, Qingzhi Ji… in Scientific Reports (2016)

Article

Glucosidase inhibitory activity and antioxidant activity of flavonoid compound and triterpenoid compound from Agrimonia Pilosa Ledeb

In Chinese traditional medicine, Agrimonia pilosa Ledeb (APL) exhibits great effect on treatment of type 2 diabetes mellitus (T2DM), however its mechanism is still unknown. Considering that T2DM are correlated wi...

** Liu, Liancai Zhu, Jun Tan, Xuemei Zhou… in BMC Complementary and Alternative Medicine (2014)

Article

Electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs

In this study, electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs were successfully fabricated through a one-step, single-nozzle electrospinning technique. Fie...

Yazhou Wang, Weili Qiao, Bochu Wang, Yiqiong Zhang, Pengyu Shao… in Polymer Journal (2011)