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Article
Unveiling the Hidden Impact: Hematoma Volumes Unravel Circuit Disruptions in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) imposes a significant burden on patients, and the volume of hematoma plays a crucial role in determining the severity and prognosis of ICH. Although significant recent progress h...
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Article
Open AccessTripartite motif containing 26 prevents steatohepatitis progression by suppressing C/EBPδ signalling activation
Currently potential preclinical drugs for the treatment of nonalcoholic steatohepatitis (NASH) and NASH-related pathopoiesis have failed to achieve expected therapeutic efficacy due to the complexity of the pa...
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Article
Open AccessHepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK
Nonalcoholic steatohepatitis (NASH), a common clinical disease, is becoming a leading cause of hepatocellular carcinoma (HCC). Dual specificity phosphatase 22 (DUSP22, also known as JKAP or JSP-1) expressed in...
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Article
Open AccessFunctional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl
Dendrobium nobile Lindl. has been used as a traditional Chinese medicine for a long time, in which the most important compound is dendrobine functioning in a variety of pharmacological activities. Farnesyl diphos...
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Article
Open AccessThe E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes
Systemic metabolic syndrome significantly increases the risk of morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). However, no effectiv...
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Article
Open AccessKeratin-A6ACA NPs for gastric ulcer diagnosis and repair
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Article
Modifying the Microenvironment of Epoxy Resin to Improve the Activity of Immobilized 7α-Hydroxysteroid Dehydrogenases
7α-Hydroxysteroid dehydrogenase (7α-HSDH) is one of the key enzymes in the catalytic reaction of taurochenodeoxycholic acid (TCDCA). To improve the activity of immobilized 7α-HSDH, the microenvironment of immo...
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Article
Comparative transcriptome analysis of the fungus Gibberella zeae transforming lithocholic acid into ursodeoxycholic acid
The comparative transcriptome analysis of the fungus Gibberella zeae which could efficiently catalyze the 7β-hydroxylation of LCA to produce UDCA was performed with LCA induction. This is the first time to report...
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Article
Future perspective: high-throughput construction of new ultrasensitive cytokine and virion liquid chips for high-throughput screening (HTS) of anti-inflammatory drugs or clinical diagnosis and treatment of inflammatory diseases
Pathogen–host cell interactions play an important role in many human infectious and inflammatory diseases. Several pathogens, including Escherichia coli (E. coli), Mycobacterium tuberculosis (M. tb), and even the...
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Article
Hair keratin promotes wound healing in rats with combined radiation-wound injury
Keratins derived from human hair have been suggested to be particularly effective in general surgical wound healing. However, the healing of a combined radiation-wound injury is a multifaceted regenerative pro...
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Article
Open AccessEstablishment of an Experimental Intracerebral Haemorrhage Model for Mass Effect Research using a Thermo-sensitive Hydrogel
The mechanical response of brain tissue closely relates to cerebral blood flow and brain diseases. During intracerebral haemorrhage (ICH), a mass effect occurs during the initial bleeding and results in signif...
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Article
Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence
Artificial intelligence (AI)-based methods have emerged as powerful tools to transform medical care. Although machine learning classifiers (MLCs) have already demonstrated strong performance in image-based dia...
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Article
Keratin nanoparticles-coating electrospun PVA nanofibers for potential neural tissue applications
Keratin has the potential to improve biocompatibility and bioactivity of polymeric nanofibers. However, the addition of keratin into the blend nanofiber would decrease the mechanical properties of nanofibers d...
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Article
Open AccessNeural Injuries Induced by Hydrostatic Pressure Associated With Mass Effect after Intracerebral Hemorrhage
Mass effect induced by growing hematoma is one of the mechanisms by which intracerebral hemorrhage (ICH) may result in brain injuries. Our goal was to investigate the damage mechanism of hydrostatic pressure a...
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Article
Open AccessDevelopment of keratin nanoparticles for controlled gastric mucoadhesion and drug release
Nanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms delivery depending on the mucoadhesive interaction, and keratin has been applied for biomedical applications ...
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Article
The effects of flavonoid compound from Agrimonia pilosa Ledeb on promotting 3T3-L1 preadipocytes differentiation by activating PPARγ partially
This study aimed to investigate the mechanism of intervening type II diabetes by flavonoid compound from Agrimonia pilosa Ledeb in vitro. We found flavonoid compound exhibited moderate peroxisome proliferator-act...
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Article
A root penetration model of Arabidopsis thaliana in phytagel medium with different strength
Phytagel media were evaluated as systems to mechanically impede roots of A. thaliana. Studying mechanical properties of Phytagel and exploring the root response to mechanical stimulation can facilitate plant cult...
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Article
Open AccessDiscovery of tauroursodeoxycholic acid biotransformation enzymes from the gut microbiome of black bears using metagenomics
Tauroursodeoxycholic acid (TUDCA) has been used to treat many diseases effectively. 7α-hydroxysteroid dehydrogenase (7α-HSDH) and 7β-hydroxysteroid dehydrogenase (7β-HSDH) are two key enzymes that drive the ef...
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Article
Comparative analysis of the gut microbiota of black bears in China using high-throughput sequencing
The Asiatic black bear (Ursus thibetanus) is a protected species from eastern Asia. In China, the Asiatic black bear occurs in 17 provinces from northeast to southwest regions. To date, information on microbial d...
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Article
A novel perspective on neuron study: damaging and promoting effects in different neurons induced by mechanical stress
A growing volume of experimental evidence demonstrates that mechanical stress plays a significant role in growth, proliferation, apoptosis, gene expression, electrophysiological properties and many other aspec...
