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Article
Genomic attributes of prostate cancer across primary and metastatic noncastrate and castrate resistant disease states: a next generation sequencing study of 183 patients
Primary prostatic adenocarcinoma (pPC) undergoes genomic evolution secondary to therapy-related selection pressures as it transitions to metastatic noncastrate (mNC-PC) and castrate resistant (mCR-PC) disease....
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Article
Pseudoendocrine sarcoma: clinicopathologic, molecular, and epigenetic features of one case
Pseudoendocrine sarcoma (PES) is a recently described neoplasm typically arising in paravertebral soft tissues. Histologically, PES resembles well-differentiated neuroendocrine tumors but lacks expression of e...
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Article
FGFR2-IIIb Expression by Immunohistochemistry Has High Specificity in Cholangiocarcinoma with FGFR2 Genomic Alterations
FGFR2 genomic alterations are observed in 10–20% of cholangiocarcinoma (CCA). Although FGFR2 fusions are an important actionable target, FGFR2 protein expression has not been thoroughly characterized.
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Article
Open AccessCorrection: A SISCAPA-based approach for detection of SARS-CoV-2 viral antigens from clinical samples
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Article
Open AccessA SISCAPA-based approach for detection of SARS-CoV-2 viral antigens from clinical samples
SARS-CoV-2, a novel human coronavirus, has created a global disease burden infecting > 100 million humans in just over a year. RT-PCR is currently the predominant method of diagnosing this viral infection alth...
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Article
Intracranial angiomatoid fibrous histiocytoma with rhabdoid features: a mimic of rhabdoid meningioma
Angiomatoid fibrous histiocytoma (AFH) is an uncommon soft-tissue neoplasm that arises mostly in the extremities of young people and generally carries a good prognosis. Intracranial location is unusual and fre...
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Chapter
Cholangiocarcinoma
Cholangiocarcinoma (CCA) is most strongly associated with risk factors characterized by chronic inflammatory states. However, most CCAs are sporadic, with no identifiable risk factors. In this chapter, we prov...
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Article
Open AccessNovel BRAF alteration in desmoplastic infantile ganglioglioma with response to targeted therapy
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Article
Open AccessComputer-Aided Nodule Assessment and Risk Yield (CANARY) may facilitate non-invasive prediction of EGFR mutation status in lung adenocarcinomas
Computer-Aided Nodule Assessment and Risk Yield (CANARY) is quantitative imaging analysis software that predicts the histopathological classification and post-treatment disease-free survival of patients with a...
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Article
Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism
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Article
Open AccessImpact of RNA degradation on fusion detection by RNA-seq
RNA-seq is a well-established method for studying the transcriptome. Popular methods for library preparation in RNA-seq such as Illumina TruSeq® RNA v2 kit use a poly-A pulldown strategy. Such methods can caus...
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Article
Distinctive Tumor Biology of MSI-High Colorectal Cancer
High-frequency microsatellite instability (MSI-H) accounts for roughly 15 % of all cases of colorectal cancer (CRC) and results from pathogenic mutations or epigenetic changes in mismatch repair (MMR) proteins...
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Article
Open AccessTargeted deep sequencing of mucinous ovarian tumors reveals multiple overlap** RAS-pathway activating mutations in borderline and cancerous neoplasms
Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We ...
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Article
Open AccessHigh-grade endometrial stromal sarcoma as the initial presentation of an adult patient with Peutz-Jeghers Syndrome: a case report
A 46-year-old female presents with a pelvic mass and is diagnosed as having a high-grade endometrial stromal sarcoma. During surgery, she is noted to have areas of intussusception of the small bowel secondary ...
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Article
Clinical diagnostic testing for the cytogenetic and molecular causes of male infertility: the Mayo Clinic experience
Approximately 8% of couples attempting to conceive are infertile and male infertility accounts for approximately 50% of infertility among couples. Up to 25% of males with non-obstructive infertility have chrom...
