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Article
Heterogeneity of PD-L1 expression between invasive and lepidic components of lung adenocarcinomas
The dynamics of PD-L1 expression are poorly understood over the development of lung adenocarcinomas from pre-invasive lesions to fully invasive carcinomas. Given the importance of PD-L1 expression for the sele...
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Article
Scrambler therapy for chemotherapy neuropathy: a randomized phase II pilot trial
Chemotherapy-induced peripheral neuropathy (CIPN) is a prominent clinical problem, with limited effective therapies. Preliminary non-randomized clinical trial data support that Scrambler Therapy is helpful in ...
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Article
STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation
STEAP4 (six-transmembrane epithelial antigen of the prostate 4) is a metalloreductase that has been shown previously to protect cells from inflammatory damage. Genetic variants in STEAP4 have been associated w...
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Article
Scrambler Therapy for the management of chronic pain
Chronic pain is a widespread and debilitating condition, encountered by physicians in a variety of practice settings. Although many pharmacologic and behavioral strategies exist for the management of this cond...
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Article
Zoledronic acid for treatment of osteopenia and osteoporosis in women with primary breast cancer undergoing adjuvant aromatase inhibitor therapy: a 5-year follow-up
This study was designed to explore whether zoledronic acid could prevent expected loss of bone mineral density (BMD) in postmenopausal women with pre-existing osteopenia or osteoporosis who were initiating adj...
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Article
National Cancer Institute-supported chemotherapy-induced peripheral neuropathy trials: outcomes and lessons
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common and debilitating complications of cancer treatment. Due to a lack of effective management options for patients with CIPN, the Nationa...
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Article
Distinctive Tumor Biology of MSI-High Colorectal Cancer
High-frequency microsatellite instability (MSI-H) accounts for roughly 15 % of all cases of colorectal cancer (CRC) and results from pathogenic mutations or epigenetic changes in mismatch repair (MMR) proteins...