24 Result(s)
within
Biomedicine
Clinical Nutrition
Human Genetics
Ben Ep**er
-
Article
Harnessing Nutrigenomics: Development of web-based communication, databases, resources, and tools
Nutrient — gene interactions are responsible for maintaining health and preventing or delaying disease. Unbalanced diets for a given genotype lead to chronic diseases such as obesity, diabetes, cardiovascular,...
-
Article
Open AccessPersonalized nutrition from a health perspective: luxury or necessity?
-
Article
Open AccessThe challenges for molecular nutrition research 1: linking genotype to healthy nutrition
Nutrition science finds itself at a major crossroad. On the one hand we can continue the current path, which has resulted in some substantial advances, but also many conflicting messages which impair the trust...
-
Article
Open AccessThe challenges for molecular nutrition research 2: quantification of the nutritional phenotype
In quantifying the beneficial effect of dietary interventions in healthy subjects, nutrition research meets a number of new challenges. Inter individual variation in biomarker values often is larger than the e...
-
Article
The challenges for molecular nutrition research 4: the “nutritional systems biology level”
Nutritional systems biology may be defined as the ultimate goal of molecular nutrition research, where all relevant aspects of regulation of metabolism in health and disease states at all levels of its complex...
-
Article
The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level
Human nutrition and metabolism may serve as the paradigm for the complex interplay of the genome with its environment. The concept of nutrigenomics now enables science with new tools and comprehensive analytic...
-
Article
Open AccessThe NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation
-
Article
Open AccessShort-term fatty acid intervention elicits differential gene expression responses in adipose tissue from lean and overweight men
The goal of this study was to investigate the effect of a short-term nutritional intervention on gene expression in adipose tissue from lean and overweight subjects. Gene expression profiles were measured afte...
-
Article
Open AccessEffect of body fat distribution on the transcription response to dietary fat interventions
Combination of decreased energy expenditure and increased food intake results in fat accumulation either in the abdominal site (upper body obesity, UBO) or on the hips (lower body obesity, LBO). In this study,...
-
Article
Owner controlled data exchange in nutrigenomic collaborations: the NuGO information network
New ‘omics’ technologies are changing nutritional sciences research. They enable to tackle increasingly complex questions but also increase the need for collaboration between research groups. An important chal...
-
Article
Open AccessChallenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies
The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioacti...
-
Article
Open AccessThe Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research
Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, ...
-
Article
Connecting the Human Variome Project to nutrigenomics
Nutrigenomics is the science of analyzing and understanding gene–nutrient interactions, which because of the genetic heterogeneity, varying degrees of interaction among gene products, and the environmental div...
-
Article
The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein
Breast cancer is the leading cause of cancer deaths in women. Diet and lifestyle are major contributing factors to increased breast cancer risk. While mechanisms underlying dietary protection of mammary tumor ...
-
Article
The nutrition researcher cohort: toward a new generation of nutrition research and health optimization
-
Article
Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life
Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum’s one gene—one polypeptide hypothesis, thereby reducing biological processes to s...
-
Article
Multivitamin restriction increases adiposity and disrupts glucose homeostasis in mice
A strong association between obesity and low plasma concentrations of vitamins has been widely reported; however, the causality of this relationship is still not established. Our goal was to evaluate the impac...
-
Article
Open AccessPhenotypic flexibility as key factor in the human nutrition and health relationship
Metabolic adaptation to a disturbance of homeostasis is determined by a series of interconnected physiological processes and molecular mechanisms that can be followed in space (i.e., different organs or organe...
-
Article
Open AccessWhite adipose tissue reference network: a knowledge resource for exploring health-relevant relations
Optimal health is maintained by interaction of multiple intrinsic and environmental factors at different levels of complexity—from molecular, to physiological, to social. Understanding and quantification of t...
-
Article
Open AccessPhenotypic flexibility as a measure of health: the optimal nutritional stress response test
Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life...
