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Article
Open AccessPropelling the paradigm shift from reductionism to systems nutrition
The complex physiology of living organisms represents a challenge for mechanistic understanding of the action of dietary bioactives in the human body and of their possible role in health and disease. Animal, c...
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Human nutrition, environment, and health
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Article
Open AccessA user-friendly workflow for analysis of Illumina gene expression bead array data available at the arrayanalysis.org portal
Illumina whole-genome expression bead arrays are a widely used platform for transcriptomics. Most of the tools available for the analysis of the resulting data are not easily applicable by less experienced use...
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Article
Open AccessNetwork-based integration of molecular and physiological data elucidates regulatory mechanisms underlying adaptation to high-fat diet
Health is influenced by interplay of molecular, physiological and environmental factors. To effectively maintain health and prevent disease, health-relevant relations need to be understood at multiple levels o...
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Article
Open AccessWhite adipose tissue reference network: a knowledge resource for exploring health-relevant relations
Optimal health is maintained by interaction of multiple intrinsic and environmental factors at different levels of complexity—from molecular, to physiological, to social. Understanding and quantification of t...
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Article
Open AccessNetwork signatures link hepatic effects of anti-diabetic interventions with systemic disease parameters
Multifactorial diseases such as type 2 diabetes mellitus (T2DM), are driven by a complex network of interconnected mechanisms that translate to a diverse range of complications at the physiological level. To o...
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Open AccessA systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone
Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone whereas most published studies...
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Article
Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life
Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum’s one gene—one polypeptide hypothesis, thereby reducing biological processes to s...
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Article
Open AccessEvaluation of multiple variate selection methods from a biological perspective: a nutrigenomics case study
Genomics-based technologies produce large amounts of data. To interpret the results and identify the most important variates related to phenotypes of interest, various multivariate regression and variate selec...
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Article
Open AccessBlimp1 regulates the transition of neonatal to adult intestinal epithelium
In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of the suckling period. These complex developmental ...
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Article
Open AccessChallenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies
The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioacti...
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Open AccessFilling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis
The application of high-throughput genomic tools in nutrition research is a widespread practice. However, it is becoming increasingly clear that the outcome of individual expression studies is insufficient for...
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Open AccessEffect of body fat distribution on the transcription response to dietary fat interventions
Combination of decreased energy expenditure and increased food intake results in fat accumulation either in the abdominal site (upper body obesity, UBO) or on the hips (lower body obesity, LBO). In this study,...
