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  1. No Access

    Article

    Proliferation-dependent induction of apoptosis by the retinoid CD437 in p53-mutated keratinocytes

    6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-Naphthalene carboxylic acid (CD437) is a synthetic retinoid with strong apoptogenic properties in various neoplastic cell lines. CD437 was shown to induce apoptosis in ma...

    R. Wanner, U. Henseleit-Walter, B. Wittig, G. Kolde in Journal of Molecular Medicine (2002)

  2. Article

    Open Access

    Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma

    Natural killer-like T lymphocytes termed cytokine-induced killer (CIK) cells have been shown to eradicate established tumours in a severe combined immune deficient (SCID) mouse/human lymphoma model. Recently, ...

    I G H Schmidt-Wolf, S Finke, B Trojaneck, A Denkena… in British Journal of Cancer (1999)

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  3. No Access

    Article

    Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study

    Recently, cytokine gene transfer into tumour cells has been shown to mediate tumour regression in animal models via immunomodulation. Consequently, a number of clinical protocols have been developed to treat c...

    P Möller, Y Sun, T Dorbic, S Alijagic, A Makki, K Jurgovsky… in British Journal of Cancer (1998)

  4. No Access

    Chapter

    Inhibition of G Proteins by Antisense Drugs

    In a multicellular organism, cells communicate with each other mostly through the cell surface, which is represented by the plasma membrane with its lipids and proteins. A subset of the membrane proteins, i.e....

    F. Kalkbrenner, B. Wittig, G. Schultz in Antisense Research and Application (1998)

  5. No Access

    Article

    Interleukin-7, interleukin-12, and GM-CSF gene transfer in patients with metastatic melanoma

    D. Schadendorf, B. M. Czarnetzki, B. Wittig in Journal of Molecular Medicine (1995)

  6. No Access

    Article

    Enormous hemangiosarcoma of the heart

    This report describes a 26-year-old patient with hemangiosarcoma of the heart and summarizes the clinicopathological features in previous reports of patients with cardiac angiosarcoma. The patient was admitted...

    W. Herr, A. Schwarting, B. Wittig, R. Wanitschke… in The clinical investigator (1994)