110 Result(s)

Article

Mikrobiom und Immuntherapien bei Tumorerkrankungen

Das intestinale Mikrobiom ist in den letzten 5 Jahren als ein wesentlicher Modulator der intestinalen und systemischen Immunregulation beschrieben worden.

Prof. Dr. E. Holler, D. Weber, D. Heudobler, D. Wolff, W. Herr in best practice onkologie (2019)

Article

Allogeneic donor split skin grafts for treatment of refractory ulcers in cutaneous chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation—a retrospective analysis on seven patients

Refractory skin ulcers due to severe chronic graft-versus-host disease (cGVHD) remain to be associated with significant morbidity and mortality.

P. Lamby, D. Wolff, S. Mielke, G. U. Grigoleit, P. Ljungman… in Annals of Hematology (2019)

Article

Mikrobiom und Immuntherapien bei Tumorerkrankungen

Das intestinale Mikrobiom ist in den letzten 5 Jahren als ein wesentlicher Modulator der intestinalen und systemischen Immunregulation beschrieben worden.

Prof. Dr. E. Holler, D. Weber, D. Heudobler, D. Wolff, W. Herr in Der Gastroenterologe (2019)

Article

Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT

Cytomegalovirus (CMV) infection is a common, potentially life-threatening complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). We assessed prospectively the safety and efficac...

M Neuenhahn, J Albrecht, M Odendahl, F Schlott, G Dössinger, M Schiemann… in Leukemia (2017)

Article

HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation

Refractory or relapsed acute myeloid leukemia (AML) represents a frequent complication after allogeneic hematopoietic stem-cell transplantation (HSCT). We show herein that primary in vitro stimulation of CD45RA-s...

W Herr, Y Eichinger, J Beshay, A Bloetz, S Vatter, C Mirbeth, E Distler… in Leukemia (2017)

Article

Altered immune reconstitution of B and T cells precedes the onset of clinical symptoms of chronic graft-versus-host disease and is influenced by the type of onset

We analyzed lymphocyte subpopulations and cytokines 3 months after allogeneic hematopoietic stem cell transplantation aiming to identify predictive cellular and serum markers for chronic graft-versus-host dise...

E.-M. Bohmann, U. Fehn, B. Holler, D. Weber, E. Holler, W. Herr… in Annals of Hematology (2017)

Article

Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation

Intestinal dysbiosis has been associated with acute gastrointestinal GvHD and poor outcome following allogeneic stem cell transplantation (ASCT). To assess the effect of a switch in 2012 from ciprofloxacin/met...

D Weber, P J Oefner, K Dettmer, A Hiergeist, J Koestler… in Bone Marrow Transplantation (2016)

Article

Azacitidine in combination with intensive induction chemotherapy in older patients with acute myeloid leukemia: The AML-AZA trial of the study alliance leukemia

DNA methylation changes are a constant feature of acute myeloid leukemia. Hypomethylating drugs such as azacitidine are active in acute myeloid leukemia (AML) as monotherapy. Azacitidine monotherapy is not cur...

C Müller-Tidow, P Tschanter, C Röllig, C Thiede, A Koschmieder, M Stelljes… in Leukemia (2016)

Article

Depletion of naive T cells using clinical grade magnetic CD45RA beads: a new approach for GVHD prophylaxis

Depletion of naive T cells from donor leukapheresis products (LPs) aims at the reduction of alloreactivity, while preserving memory T-cell reactivity (for example, to pathogens). This study established the imm...

D Teschner, E Distler, D Wehler, M Frey, D Marandiuc… in Bone Marrow Transplantation (2014)

Article

Donor CD4 T cells convert mixed to full donor T-cell chimerism and replenish the CD52-positive T-cell pool after alemtuzumab-based T-cell-depleted allo-transplantation

Donor lymphocyte infusions (DLI) are used to resolve mixed T-cell chimerism (TCC) after allo-SCT despite a substantial risk of GVHD. We analyzed the impact of prophylactic CD8-depleted (CD8^depl) DLI in 20 recipie...

R G Meyer, E M Wagner, A Konur, K Bender, T Schmitt… in Bone Marrow Transplantation (2010)

Article

Serotherapy with thymoglobulin and alemtuzumab differentially influences frequency and function of natural killer cells after allogeneic stem cell transplantation

Although thymoglobulin and alemtuzumab are frequently used in hematopoietic stem cell transplantation (HSCT), little is known of their effects on NK cells, which mediate important functions in post-transplanta...

O Penack, L Fischer, A Stroux, C Gentilini, A Nogai… in Bone Marrow Transplantation (2008)

Article

Infusion of bcr/abl peptide-reactive donor T cells to achieve molecular remission of chronic myeloid leukemia after CD34⁺ selected allogeneic hematopoietic cell transplantation

M Bornhauser, C Thiede, J Babatz, J Schetelig, T Illmer, A Kiani, U Platzbecker… in Leukemia (2006)

Article

Depletion of alloreactive T cells via CD69: implications on antiviral, antileukemic and immunoregulatory T lymphocytes

Selective depletion of alloreactive T cells from stem-cell allografts should abrogate graft-versus-host disease while preserving beneficial T cell specificities to facilitate engraftment and immune reconstitut...

U F Hartwig, M Nonn, S Khan, R G Meyer, C Huber, W Herr in Bone Marrow Transplantation (2006)

Chapter

Tumorvakzine

Verschiedene klinische Beobachtungen unterstützen die Vermutung, daß das Immunsystem bei der Bekämpfung von Tumorzellen eine wichtige Rolle spielt. Hierzu zählen