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Chapter and Conference Paper
Antimetastatic Potential in Mice after Gene Therapy with Plasmid AMEP
Gene electrotransfer of Plasmid AMEP is a new antiangiogenic approach in cancer treatment. While the local effects after intratumoral administration have been already studied, systemic effects still need to be...
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Article
Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma
Gene therapy with Plasmid AMEP (antiangiogenic metargidin peptide) has recently been studied as a potential targeted therapy for melanoma. This plasmid is designed to downregulate α5β1 and αvβ3 integrins. In o...
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Article
Photosynthesis of ozone-sensitive and -resistant Phaseolus vulgaris genotypes under ambient ozone and moderate heat stress
Physiological responses from sensitive (S156) and resistant (R123) genotypes of ozone bioindicator, snap bean, were investigated after exposing the plants to cumulative, phytotoxic ozone amounts. Daily course ...
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Article
Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model
Lysosomal cysteine cathepsins contribute to proteolytic events promoting tumor growth and metastasis. Their enzymatic activity, however, is tightly regulated by endogenous inhibitors. To investigate the role o...
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Article
Open AccessSiramesine triggers cell death through destabilisation of mitochondria, but not lysosomes
A sigma-2 receptor agonist siramesine has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. However, its mechanism of action is still poorly understood. We show...
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Article
High-Quality AlGaN/GaN Grown on Sapphire by Gas-Source Molecular Beam Epitaxy using a Thin Low-Temperature AlN Layer
Growth of high-quality AlGaN/GaN heterostructures on sapphire by ammonia gassource molecular beam epitaxy is reported. Incorporation of a thin AlN layer grown at low temperature within the GaN buffer is shown ...
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Article
Open AccessMAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis
A major feature of apoptotic cell death is gross structural changes, one of which is the loss of cell–cell contacts. The caspases, executioners of apoptosis, were shown to cleave several proteins involved in t...
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Article
Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice
Expression levels of the papain-like cysteine protease cathepsin B (Ctsb) have been positively correlated with mammary tumour progression and metastasis; however, its roles in the hallmark processes of maligna...
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Article
A cortical-bone structural geometry phantom: dental plaster as a convenient and radiologically similar fabrication material
Areal bone mineral density (aBMD), derived from dual-energy X-ray absorptiometry (DXA) scanners is used routinely to infer bone strength. With DXA hip scans there is growing acceptance of the advantages of als...
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Article
Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1)
Apoptosis can be mediated by mechanisms other than the traditional caspase-mediated cleavage cascade. There is growing recognition that alternative proteolytic enzymes such as the lysosomal cathepsin proteases...
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Article
Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity
We report here that a number of commonly used small peptide caspase inhibitors consisting of a caspase recognition sequence linked to chloromethylketone, fluoromethylketone or aldehyde reactive group efficient...
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Article
High-Quality AlGaN/GaN Grown on Sapphire by Gas-Source Molecular Beam Epitaxy using a Thin Low-Temperature AlN Layer
Growth of high-quality AlGaN/GaN heterostructures on sapphire by ammonia gas-source molecular beam epitaxy is reported. Incorporation of a thin AlN layer grown at low temperature within the GaN buffer is shown...
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Article
Bioindication of Different Stresses in Forest Decline Studies in Slovenia
Determination of the stresses operating on a forest ecosystem demands the use of several bioindication methods. Air quality indicators were assessed from an inventory of forest decline based on the assessment ...
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Chapter
Bioindication of Different Stresses in Forest Decline Studies in Slovenia
Determination of the stresses operating on a forest ecosystem demands the use of several bioindication methods. Air quality indicators were assessed from an inventory of forest decline based on the assessment ...
