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Article
Open AccessRegulation of Respiration and Apoptosis by Cytochrome c Threonine 58 Phosphorylation
Cytochrome c (Cytc) is a multifunctional protein, acting as an electron carrier in the electron transport chain (ETC), where it shuttles electrons from bc1 complex to cytochrome c oxidase (COX), and as a trigger ...
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Article
Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
T cell–antigen receptor (TCR) signaling requires the sequential activities of the kinases Lck and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, thus leading to the recruitment, phosphorylation, and ...
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Chapter
Proteomic Tools for the Investigation of Nodule Organogenesis
Over the last decades, proteomics approaches are increasingly being utilized to develop a more comprehensive picture of in many models and/or economically important legume species. This chapter provides an o...
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Protocol
Phosphoproteomic Analysis of Liver Homogenates
Regulation of protein function via reversible phosphorylation is an essential component of cell signaling. Our ability to understand complex phosphorylation networks in the physiological context of a whole org...
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Chapter and Conference Paper
Phosphoproteomic Analysis of Lymphocyte Signaling
Through fusion of innovations in high-throughput chromatographic separations of phosphopeptides, detection by mass spectrometry, and bioinformatic analysis, we have assembled a formidable tool to complement th...
