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Article
The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies
Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population’s high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be...
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Article
A Pilot Assessment of the Effects of HIV and Methamphetamine Dependence on Socially Dysregulated Behavior in the Human Behavioral Pattern Monitor
Deficits in social cognition are seen in both people living with HIV (PWH) and people with a history of methamphetamine (METH) dependence. Dually affected individuals may experience additive negative effects o...
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Article
Correction to: Deriving psychiatric symptom-based biomarkers from multivariate relationships between psychophysiological and biochemical measures
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Article
Deriving psychiatric symptom-based biomarkers from multivariate relationships between psychophysiological and biochemical measures
Identification of biomarkers for psychiatric disorders remains very challenging due to substantial symptom heterogeneity and diagnostic comorbidity, limiting the ability to map symptoms to underlying neurobiol...
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Article
HIV Transgenic Rats Demonstrate Superior Task Acquisition and Intact Reversal Learning in the Within-Session Probabilistic Reversal Learning Task
The HIV transgenic (HIVtg) rat is a commonly used animal model of chronic HIV infection that exhibits a wide range of cognitive deficits. To date, relatively little work has been conducted on these rats’ capac...
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Chapter
Integrating Motivational Interviewing into Pulmonary Healthcare
Motivational Interviewing (MI) is a communication style intended to help people make difficult behavior changes. Individuals with pulmonary disease often struggle with making healthy changes (e.g., quitting sm...
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Article
Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research
HIV-1 infection causes injury to the central nervous system (CNS) and is often associated with neurocognitive disorders. One model for brain damage seen in AIDS patients is the transgenic (tg) mouse expressing...
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Article
Open AccessErratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk
Nature Communications 8: Article number: 15805 (2017); Published: 14 June 2017; Updated: 2 August 2017 In Supplementary Fig. 10 of this Article, images for panels a and b were inadvertently omitted. The correc...
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Article
Open AccessGenetic loci associated with heart rate variability and their effects on cardiac disease risk
Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies f...
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Article
Effects of HIV and Methamphetamine on Brain and Behavior: Evidence from Human Studies and Animal Models
Methamphetamine (Meth) use is frequent among HIV-infected persons. Combined HIV and Meth insults may exacerbate neural injury in vulnerable neuroanatomic structures or circuitries in the brain, leading to incr...
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Article
Amphetamine increases activity but not exploration in humans and mice
Cross-species quantification of physiological behavior enables a better understanding of the biological systems underlying neuropsychiatric diseases such as bipolar disorder (BD). Cardinal symptoms of manic BD...
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Chapter
Locomotor Profiling from Rodents to the Clinic and Back Again
The quantification of unconditioned motoric activity is one of the oldest and most commonly utilized tools in behavioral studies. Although typically measured in reference to psychiatric disorders, e.g., amphet...
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Article
Reduced Dopamine Transporter Functioning Induces High-Reward Risk-Preference Consistent with Bipolar Disorder
Individuals with bipolar disorder (BD) exhibit deleterious decision making, negatively impacting their lives. Such aberrant decision making can be quantified using the Iowa Gambling Task (IGT), which requires ...
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Article
Open AccessEffect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm
Methamphetamine (MA) is an addictive psychostimulant associated with neurocognitive impairment, including inhibitory deficits characterized by a reduced ability to control responses to stimuli. While various d...
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Article
Open AccessGBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior
Mania is a core feature of bipolar disorder (BD) that traditionally is assessed using rating scales. Studies using a new human behavioral pattern monitor (BPM) recently demonstrated that manic BD patients exhi...
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Article
Adults with Autism Show Increased Sensitivity to Outcomes at Low Error Rates During Decision-Making
Decision-making is an important function that can be quantified using a two-choice prediction task. Individuals with Autistic Disorder (AD) often show highly restricted and repetitive behavior that may interfe...
