16 Result(s)
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Virawudh Soontornniyomkij
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Article
Open AccessAlzheimer-Type Cerebral Amyloidosis in the Context of HIV Infection: Implications for a Proposed New Treatment Approach
Reverse transcriptase inhibitors (RTIs) are currently broadly prescribed for the treatment of HIV infection but are also thought to prevent Alzheimer’s disease (AD) progression by protecting against amyloidosi...
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The relationship between synaptodendritic neuropathology and HIV-associated neurocognitive disorders is moderated by cognitive reserve
We examined whether cognitive reserve moderated the relationship between neurodegeneration and cognition in 67 postmortem persons with HIV (PWH) who were cognitively assessed within 1 year of death. Cognitive ...
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Article
CSF markers of AD-related pathology relate specifically to memory impairment in older people with HIV: a pilot study
Given the co-occurrence of memory impairment in HIV-associated neurocognitive disorders (HAND) and amnestic mild cognitive impairment/Alzheimer’s disease (aMCI/AD), biomarkers are needed that can disentangle t...
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Article
Correction to: A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders
Due to a production error data in Table 1 were not presented correctly.
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Article
A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders
HIV-associated neurocognitive disorders (HAND) describe a spectrum of neuropsychological impairment caused by HIV-1 infection. While the sequence of cellular and physiological events that lead to HAND remains ...
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Article
Associations of regional amyloid-β plaque and phospho-tau pathology with biological factors and neuropsychological functioning among HIV-infected adults
With increasing age, the general population is increasingly vulnerable to the development of cerebral amyloid-β (Aβ) plaque and neuronal phospho-tau (p-tau) pathology. In HIV disease, prior studies of these ne...
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Article
Lifetime methamphetamine dependence is associated with cerebral microgliosis in HIV-1-infected adults
Methamphetamine (Meth) use is common among HIV-infected persons. It remains unclear whether Meth dependence is associated with long-lasting degenerative changes in the brain parenchyma and microvasculature of ...
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Effects of HIV and Methamphetamine on Brain and Behavior: Evidence from Human Studies and Animal Models
Methamphetamine (Meth) use is frequent among HIV-infected persons. Combined HIV and Meth insults may exacerbate neural injury in vulnerable neuroanatomic structures or circuitries in the brain, leading to incr...
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Article
Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV
The neuropathogenesis of HIV-associated neurocognitive disorders (HAND) remains puzzling. We interrogated several levels of data (host genetic, histopathology, brain viral load, and neurocognitive) to identify...
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Article
Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders
HIV infection leads to age-related conditions in relatively young persons. HIV-associated neurocognitive disorders (HAND) are considered among the most prevalent of these conditions. To study the mechanisms un...
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Article
Antioxidant Sestrin-2 Redistribution to Neuronal Soma in Human Immunodeficiency Virus-Associated Neurocognitive Disorders
Sestrin-2 is involved in p53-dependent antioxidant defenses and in the maintenance of metabolic homeostasis. We hypothesize that sestrin-2 expression is altered in the brains of subjects diagnosed with human i...
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Article
Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders
FK506 binding protein (FKBP)-51 and FKBP52 act as molecular chaperones to control glucocorticoid receptor (GR) sensitivity. Dysregulation of proteins involved in GR-mediated signaling can lead to maladaptive s...
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Article
Open AccessIncreased hippocampal accumulation of autophagosomes predicts short-term recognition memory impairment in aged mice
Constitutive macroautophagy involved in the turnover of defective long-lived proteins and organelles is crucial for neuronal homeostasis. We hypothesized that macroautophagic dysregulation in selective brain r...
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Article
Open AccessShort-term recognition memory impairment is associated with decreased expression of FK506 binding protein 51 in the aged mouse brain
Evidence suggests that increased glucocorticoid receptor (GR) signaling may contribute to cognitive decline with age. We hypothesized that alterations in GR signaling pathway molecules, FK506 binding protein (...
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Article
Open AccessDifferential Expression of Immunophilins FKBP51 and FKBP52 in the Frontal Cortex of HIV-Infected Patients with Major Depressive Disorder
Patients infected with human immunodeficiency virus (HIV) have a higher risk of develo** major depressive disorder (MDD) than the general population. Immunophilins FKBP51 and FKBP52 are expressed in cortical...
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Article
Absence of brain-derived neurotrophic factor and trkB receptor immunoreactivity in glia of Alzheimer’s disease
Alterations in the neuronal expression of some neurotrophins have been shown in various neurodegenerative processes, particularly Alzheimer’s disease (AD). Glia may up-regulate neurotrophins and their high-af...
