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Article
Redox metabolism modulation as a mechanism in SSRI toxicity and pharmacological effects
Depressive disorders are amongst the greatest mental health challenges, with an increasing number of patients being diagnosed each year. Though it has not yet been fully elucidated, redox metabolism imbalances...
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Article
Open AccessPro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model
Silica nanoparticles (SiNPs) are among the most widely manufactured and used nanoparticles. Concerns about potential health effects of SiNPs have therefore risen. Using a 3D tri-culture model of the alveolar l...
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Article
Xenopus laevis as a Bioindicator of Endocrine Disruptors in the Region of Central Chile
One of the direct causes of biodiversity loss is environmental pollution resulting from the use of chemicals. Different kinds of chemicals, such as persistent organic pollutants and some heavy metals, can be e...
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Article
Genetic and systemic toxicity induced by silver and copper oxide nanoparticles, and their mixture in Clarias gariepinus (Burchell, 1822)
Unanticipated increase in the use of silver (Ag) and copper oxide (CuO) nanoparticles (NPs) due to their antimicrobial properties is eliciting environmental health concern because of their coexistence in the a...
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Article
Open AccessIn vitro exposure of a 3D-tetraculture representative for the alveolar barrier at the air-liquid interface to silver particles and nanowires
The present study aimed to evaluate the potential differences in the biological effects of two types of spherical silver particles of 20 and 200 nm (Ag20 and Ag200), and of PVP-coated silver nanowires (AgNWs) ...
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Article
Open AccessIdentification of reference genes for RT-qPCR data normalization in Gammarus fossarum (Crustacea Amphipoda)
Gene expression profiling via RT-qPCR is a robust technique increasingly used in ecotoxicology. Determination and validation of optimal reference genes is a requirement for initiating RT-qPCR experiments. To o...
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Article
Open AccessLipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s)
Exposure to traffic-derived particulate matter (PM), such as diesel exhaust particles (DEP), is a leading environmental cause of cardiovascular disease (CVD), and may contribute to endothelial dysfunction and ...
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Article
Respiratory sensitization: toxicological point of view on the available assays
Respiratory sensitization as a consequence of exposure to chemical products has increased over the last decades, leading to an increase of morbidity. The increased use of synthetic compounds resulted in an exp...
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Article
Open AccessEndothelial responses of the alveolar barrier in vitro in a dose-controlled exposure to diesel exhaust particulate matter
During the last 250 years, the level of exposure to combustion-derived particles raised dramatically in western countries, leading to increased particle loads in the ambient air. Among the environmental partic...
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Article
Open AccessDose-dependent autophagic effect of titanium dioxide nanoparticles in human HaCaT cells at non-cytotoxic levels
Interactions between nanoparticles and cells are now the focus of a fast-growing area of research. Though many nanoparticles interact with cells without any acute toxic responses, metal oxide nanoparticles inc...
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Article
Open AccessEffects of silver nanoparticles and ions on a co-culture model for the gastrointestinal epithelium
The increased incorporation of silver nanoparticles (Ag NPs) into consumer products makes the characterization of potential risk for humans and other organisms essential. The oral route is an important uptake ...
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Article
Open AccessInterlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA)
One of the key challenges in the field of nanoparticle (NP) analysis is in producing reliable and reproducible characterisation data for nanomaterials. This study looks at the reproducibility using a relativel...
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Article
Open AccessAn improved 3D tetraculture system mimicking the cellular organisation at the alveolar barrier to study the potential toxic effects of particles on the lung
Exposure to fine and ultra-fine ambient particles is still a problem of concern in many industrialised parts of the world and the intensified use of nanotechnology may further increase exposure to small partic...
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Article
Open AccessEndocrine Disrupting Compounds – do we need to consider thyroid hormones? Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals
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Chapter and Conference Paper
Intrauterine treated lambs as a model for the study of Intrauterine Growth Restriction (IUGR) and consequent metabolic disorders
Developmental exposure to environmental and therapeutic chemicals, including excess androgens, has been reported to induce Intrauterine Growth Restriction (IUGR) and abnormal post-natal growth. It has now been...
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Article
NanoSIMS50 — a powerful tool to elucidate cellular localization of halogenated organic compounds
Persistent organic pollutants are widely distributed in the environment and lots of toxicological data are available. However, little is known on the intracellular fate of such compounds. Here a method applyin...
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Article
Open AccessThe Health and Environment Network and its achievements
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Article
Open AccessWe’re only in it for the knowledge? A problem solving turn in environment and health expert elicitation
The FP6 EU HENVINET project aimed at synthesizing the scientific information available on a number of topics of high relevance to policy makers in environment and health. The goal of the current paper is to re...
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Article
Open AccessPolicy relevant Results from an Expert Elicitation on the Human Health Risks of Decabromodiphenyl ether (decaBDE) and Hexabromocyclododecane (HBCD)
Apply a recently developed expert elicitation procedure to evaluate the state of the current knowledge of the two brominated flame retardants (BFRs) most commonly used today; decabromo-diphenyl ether (decaBDE)...
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Article
Open AccessNanoparticles in the environment: assessment using the causal diagram approach
Nanoparticles (NPs) cause concern for health and safety as their impact on the environment and humans is not known. Relatively few studies have investigated the toxicological and environmental effects of expos...
