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  1. No Access

    Article

    Cell-type-specific 3D epigenomes in the develo** human cortex

    Lineage-specific epigenomic changes during human corticogenesis have been difficult to study owing to challenges with sample availability and tissue heterogeneity. For example, previous studies using single-ce...

    Michael Song, Mark-Phillip Pebworth, **aoyu Yang, Armen Abnousi, Changxu Fan… in Nature (2020)

  2. No Access

    Article

    Circular ecDNA promotes accessible chromatin and high oncogene expression

    Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer1,2, but our understanding of the structure of ecDNA and its effect on gene regulation is limited. Here, by integrating ultra...

    Sihan Wu, Kristen M. Turner, Nam Nguyen, Ramya Raviram, Marcella Erb… in Nature (2019)

  3. Article

    Publisher Correction: Sensory experience remodels genome architecture in neural circuit to drive motor learning

    In this Letter, ‘≥’ should be ‘≤’ in the sentence: “Intra-chromosomal reads were further split into short-range reads (≥1 kb) and long-range reads (>1 kb)”. This error has been corrected online.

    Tomoko Yamada, Yue Yang, Pamela Valnegri, Ivan Juric, Armen Abnousi… in Nature (2019)

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  4. No Access

    Article

    Sensory experience remodels genome architecture in neural circuit to drive motor learning

    Neuronal-activity-dependent transcription couples sensory experience to adaptive responses of the brain including learning and memory. Mechanisms of activity-dependent gene expression including alterations of ...

    Tomoko Yamada, Yue Yang, Pamela Valnegri, Ivan Juric, Armen Abnousi… in Nature (2019)