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Activity-Dependent Chromatin Mechanisms in Cerebellar Motor Learning
Neural circuit activity representing sensorimotor experiences trigger molecular mechanisms that drive long-lasting changes in brain circuits underlying learning and memory. Recent advancements in molecular gen...
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Article
Publisher Correction: Sensory experience remodels genome architecture in neural circuit to drive motor learning
In this Letter, ‘≥’ should be ‘≤’ in the sentence: “Intra-chromosomal reads were further split into short-range reads (≥1 kb) and long-range reads (>1 kb)”. This error has been corrected online.
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Sensory experience remodels genome architecture in neural circuit to drive motor learning
Neuronal-activity-dependent transcription couples sensory experience to adaptive responses of the brain including learning and memory. Mechanisms of activity-dependent gene expression including alterations of ...
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Open AccessConditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice
Here we have characterized the functional impairments resulting from conditional knockout of the ubiquitin-conjugating E2 enzyme (UBC13) in rodent cerebellar granule neurons, which greatly increases the parall...
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Open AccessRNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
Although ubiquitin ligases have been implicated in autism, their roles and mechanisms in brain development remain incompletely understood. Here, we report that in vivo knockdown or conditional knockout of the ...
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Article
Open AccessEpilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission
Shrm4, a protein expressed only in polarized tissues, is encoded by the KIAA1202 gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brai...
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Open AccessDisruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits
During brain development, the small GTPases Rac1/Rac3 play key roles in neuronal migration, neuritogenesis, synaptic formation and plasticity, via control of actin cytoskeleton dynamic. Their activity is posit...
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Synaptic Dysfunction and Intellectual Disability
Intellectual disability (ID) is a common and highly heterogeneous paediatric disorder with a very severe social impact. Intellectual disability can be caused by environmental and/or genetic factors. Although i...
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A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbα
This study describes how the circadian clock and regulators of synaptic activity influence each other by identifying the ways in which oligophrenin-1 (a regulator of dendritic spine morphology) and Rev-erbA (a...
