25 Result(s)

Article

Single-cell profile of tumor and immune cells in primary breast cancer, sentinel lymph node, and metastatic lymph node

Little is known about the host–tumor interaction in the lymph-node basin at a single cell level. This study examines single cell sequences in breast cancer nodal metastases of a patient with triple-negative br...

Ning Liao, Cheukfai Li, Li Cao, Yanhua Chen, Chongyang Ren, **aoqing Chen… in Breast Cancer (2023)

Article

Locoregional Management of Breast Cancer Following Neoadjuvant Chemotherapy

The treatment of breast cancer is evolving at accelerated rates. As systemic therapy continues to improve, the roles of surgery and radiation are being re-considered. The intent of this review is to discuss re...

Ashley D. Marumoto, Armando E. Giuliano in Current Breast Cancer Reports (2022)

Living Reference Work Entry In depth

Radioguided Surgery for Breast Cancer

Sentinel lymph node biopsy is the standard surgical procedure for staging clinically tumor-free regional nodes in patients with early-stage breast cancer. This technique has spared the additional morbidity of ...

Francesco Giammarile, Federica Orsini, Renato A. Valdés Olmos… in Nuclear Oncology

Article

Adjuvant endocrine therapy is associated with improved overall survival in elderly hormone receptor-positive breast cancer patients

There is controversy regarding the survival benefit of endocrine therapy (ET) in elderly patients with early invasive hormone receptor-positive (HR+) breast cancer. In this study, we characterize a single inst...

Jessica S. Crystal, Jamie Rand, Jeffrey Johnson… in Breast Cancer Research and Treatment (2020)

Article

Nomogram-based estimate of axillary nodal involvement in ACOSOG Z0011 (Alliance): validation and association with radiation protocol variations

A substantial proportion of patients enrolled on ACOSOG Z0011 received protocol-deviant radiation treatment. It is currently unknown whether these deviations involved the use of more extensive fields in patien...

Matthew S. Katz, Linda McCall, Karla Ballman… in Breast Cancer Research and Treatment (2020)

Article

FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer

Triple-negative breast cancer (TNBC) has high rates of local recurrence and distant metastasis, partially due to its high invasiveness. The Forkhead box C1 (FOXC1) transcription factor has been shown to be spe...

Bingchen Han, Bo Zhou, Ying Qu, Bowen Gao, Yali Xu, Stacey Chung… in Oncogene (2018)

Reference Work Entry In depth

Radioguided Surgery for Breast Cancer

Sentinel lymph node biopsy is the standard surgical procedure for staging clinically tumor-free regional nodes in patients with early-stage breast cancer. This technique has spared the additional morbidity o...

Francesco Giammarile, Federica Orsini, Renato A. Valdés Olmos… in Nuclear Oncology (2017)

Article

Management of the Axilla After Neoadjuvant Therapy: Current Data and Controversies

Neoadjuvant chemotherapy (NAC) is the standard treatment for patients with locally advanced breast cancer or inoperable breast cancer and is administered with the intention of downstaging the tumor. Until rece...

Alexandra Gangi, Michael Choi, Armando E. Giuliano in Current Breast Cancer Reports (2014)

Article

Individualizing Axillary Management in Breast Cancer Treatment

Management of the axilla in patients with breast cancer has evolved significantly in the last century. The status of the axillary lymph nodes continues to provide important prognostic information. However, in ...

Catherine Dang, Armando E. Giuliano in Current Breast Cancer Reports (2013)

Article

Should ACOSOG Z0011 change practice with respect to axillary lymph node dissection for a positive sentinel lymph node biopsy in breast cancer?

While any study can be criticized, the results of Z0011 clearly show that sentinel lymph node biopsy (SLNB) alone without axillary lymph node dissection (ALND) results in extremely low locoregional recurrence ...

Armando E. Giuliano, Monica Morrow, Shivani Duggal… in Clinical & Experimental Metastasis (2012)

Article

Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study

Long interspersed element 1 (LINE-1), a non-coding genomic repeat sequence, methylation status can influence tumor progression. In this study, the clinical significance of LINE-1 methylation status was assesse...

Anneke Q. van Hoesel, Cornelis J. H. van de Velde… in Breast Cancer Research and Treatment (2012)

Article

Primary tumor classification according to methylation pattern is prognostic in patients with early stage ER-negative breast cancer

Breast cancer patients with similar clinical stage may experience different disease outcomes. Aberrant DNA methylation of primary breast tumors can have impact on the clinical outcome. This study aimed to asse...

Anneke Q. van Hoesel, Cornelis J. H. van de Velde… in Breast Cancer Research and Treatment (2012)

Article

Prognostic significance of micrometastasis and isolated tumor cells in the sentinel lymph node

Junko Ozao-Choy, Armando E. Giuliano in Breast Cancer Research and Treatment (2011)

Article

Can axillary radiotherapy replace axillary dissection for early-stage breast cancer?

Farin F Amersi, Armando E Giuliano in Nature Clinical Practice Oncology (2005)

Article

Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer

ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix–loop–helix transcription factors. Certain human primary breast cancers reportedly have low or no express...

Naoyuki Umetani, Takuji Mori, Kazuo Koyanagi, Masaru Shinozaki, Joseph Kim… in Oncogene (2005)

Article

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

Purpose: Taxol has emerged as a valuable antimitotic chemotherapeutic agent, particularly in advanced breast and ovarian cancers. Although much is known about cytotoxic mechanisms, the effectiveness of Taxol can...

Anthony G. Charles, Tie-Yan Han, Yong Y. Liu… in Cancer Chemotherapy and Pharmacology (2001)