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  1. Article

    Open Access

    Early intubation and decreased in-hospital mortality in patients with coronavirus disease 2019

    Some academic organizations recommended that physicians intubate patients with COVID-19 with a relatively lower threshold of oxygen usage particularly in the early phase of pandemic. We aimed to elucidate whet...

    Ryo Yamamoto, Daiki Kaito, Koichiro Homma, Akira Endo, Takashi Tagami… in Critical Care (2022)

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  2. Article

    Open Access

    Emergency gastrointestinal surgery in patients undergoing antithrombotic therapy in a single general hospital: a propensity score-matched analysis

    This study aimed to review and evaluate the surgical outcomes, particularly intraoperative severe blood loss and postoperative blood complications, of emergency gastrointestinal surgery in patients undergoing ...

    Shinya Abe, Katsunori Ami, Akira Katsuno, Noriyasu Tamura… in BMC Gastroenterology (2021)

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  3. No Access

    Article

    Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer

    ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix–loop–helix transcription factors. Certain human primary breast cancers reportedly have low or no express...

    Naoyuki Umetani, Takuji Mori, Kazuo Koyanagi, Masaru Shinozaki, Joseph Kim… in Oncogene (2005)

  4. No Access

    Article

    Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma

    APAF-1 gene, located at chromosome locus 12q23, is a key factor in the mitochondrial apoptotic pathway downstream of p53, and is a potential tumor suppressor gene. We hypothesized that APAF-1 gene dysfunction due...

    Naoyuki Umetani, Akihide Fujimoto, Hiroya Takeuchi, Masaru Shinozaki… in Oncogene (2004)

  5. No Access

    Article

    Microsatellite Instability of Colorectal Cancer and Adenoma in Synchronous Multiple Colorectal Cancer Patients with Associated Extracolonic Malignancies

    We examined microsatellite instability (MSI) in nonfamilial multiple synchronous colorectal cancer (multiple CC) patients. We divided the patients into two groups, those with and without extracolonic primary ...

    Eiji Ueda, Toshiaki Watanabe, Hironori Ishigami, Naoyuki Umetani… in Surgery Today (2001)

  6. No Access

    Article

    Superficial depressed early carcinoma that developed into protuberant advanced carcinoma in the transverse colon

    A screening colonoscopic examination in a 70-year-old man revealed a nonpolypoid type superficial depressed early carcinoma, about 2 cm in diameter, in the transverse colon. The lesion was not resected and wa...

    Naoyuki Umetani, Tetsuichiro Muto, Yutaka J Kawamura… in Journal of Gastroenterology (2001)