40 Result(s)
within
Armando E. Giuliano
-
Article
Open AccessReciprocal regulation of forkhead box C1 and L1 cell adhesion molecule contributes to triple-negative breast cancer progression
The potential of targeting forkhead box C1 (FOXC1) as a therapeutic approach for triple-negative breast cancer (TNBC) is promising. However, a comprehensive understanding of FOXC1 regulation, particularly upst...
-
Protocol
Genome-Wide Analysis of Palindrome Formation with Next-Generation Sequencing (GAPF-Seq) and a Bioinformatics Pipeline for Assessing De Novo Palindromes in Cancer Genomes
DNA palindromes are a type of chromosomal aberration that appears frequently during tumorigenesis. They are characterized by sequences of nucleotides that are identical to their reverse complements and often a...
-
Article
Single-cell profile of tumor and immune cells in primary breast cancer, sentinel lymph node, and metastatic lymph node
Little is known about the host–tumor interaction in the lymph-node basin at a single cell level. This study examines single cell sequences in breast cancer nodal metastases of a patient with triple-negative br...
-
Article
Locoregional Management of Breast Cancer Following Neoadjuvant Chemotherapy
The treatment of breast cancer is evolving at accelerated rates. As systemic therapy continues to improve, the roles of surgery and radiation are being re-considered. The intent of this review is to discuss re...
-
Living Reference Work Entry In depth
Radioguided Surgery for Breast Cancer
Sentinel lymph node biopsy is the standard surgical procedure for staging clinically tumor-free regional nodes in patients with early-stage breast cancer. This technique has spared the additional morbidity of ...
-
Reference Work Entry In depth
Radioguided Surgery for Breast Cancer
Sentinel lymph node biopsy is the standard surgical procedure for staging clinically tumor-free regional nodes in patients with early-stage breast cancer. This technique has spared the additional morbidity of ...
-
Article
Correction to: Nomogram-based estimate of axillary nodal involvement in ACOSOG Z0011 (Alliance): validation and association with radiation protocol variations
Unfortunately, the original version of the article was published with incorrect NCT number (NCT00003854) in abstract section”.
-
Article
Open AccessIdentification of triptonide as a therapeutic agent for triple negative breast cancer treatment
Triple-negative breast cancer (TNBC) is associated with a high rate of early recurrence and distant metastasis, frequent development of therapeutic resistance, and a poor prognosis. There is a lack of targeted...
-
Article
Adjuvant endocrine therapy is associated with improved overall survival in elderly hormone receptor-positive breast cancer patients
There is controversy regarding the survival benefit of endocrine therapy (ET) in elderly patients with early invasive hormone receptor-positive (HR+) breast cancer. In this study, we characterize a single inst...
-
Article
Nomogram-based estimate of axillary nodal involvement in ACOSOG Z0011 (Alliance): validation and association with radiation protocol variations
A substantial proportion of patients enrolled on ACOSOG Z0011 received protocol-deviant radiation treatment. It is currently unknown whether these deviations involved the use of more extensive fields in patien...
-
Chapter
Axillary Surgery
Randomized clinical trials have brought about major changes in the surgical management of the axilla in patients with breast cancer. Sentinel lymph node biopsy is the standard of care for axillary staging in p...
-
Article
FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer
Triple-negative breast cancer (TNBC) has high rates of local recurrence and distant metastasis, partially due to its high invasiveness. The Forkhead box C1 (FOXC1) transcription factor has been shown to be spe...
-
Article
Open AccessInhibition of lobuloalveolar development by FOXC1 overexpression in the mouse mammary gland
The forkhead box transcription factor FOXC1 plays a critical role in embryogenesis and the development of many organs. Its mutations and high expression are associated with many human diseases including breast...
-
Article
Open AccessIdentification of EGF-NF-κB-FOXC1 signaling axis in basal-like breast cancer
The pathogenesis of human basal-like breast cancer (BLBC) is not well understood and patients with BLBC have a poor prognosis. Expression of the epidermal growth factor receptor (EGFR) and nuclear factor-κB (N...
-
Article
Open AccessPalindromic amplification of the ERBB2 oncogene in primary HER2-positive breast tumors
Oncogene amplification confers a growth advantage to tumor cells for clonal expansion. There are several, recurrently amplified oncogenes throughout the human genome. However, it remains unclear whether this r...
-
Article
Recurrent primary hyperparathyroidism due to Type 1 parathyromatosis
Parathyromatosis is a rare condition consisting of multiple nodules of benign hyperfunctioning parathyroid tissue scattered throughout the neck and superior mediastinum. As a potential cause of recurrent or pe...
-
Reference Work Entry In depth
Radioguided Surgery for Breast Cancer
Sentinel lymph node biopsy is the standard surgical procedure for staging clinically tumor-free regional nodes in patients with early-stage breast cancer. This technique has spared the additional morbidity o...
-
Article
Open AccessTranscriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs
Surface ectoderm (SE) cells give rise to structures including the epidermis and ectodermal associated appendages such as hair, eye and the mammary gland. In this study, we validate a protocol that utilizes BMP...
-
Article
Open AccessElevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study
Chromosome 1 open reading frame 63 (C1orf63) is located on the distal short arm of chromosome 1, whose allelic loss has been observed in several human cancers. C1orf63 has been reported to be up-regulated in I...
-
Article
Management of the Axilla After Neoadjuvant Therapy: Current Data and Controversies
Neoadjuvant chemotherapy (NAC) is the standard treatment for patients with locally advanced breast cancer or inoperable breast cancer and is administered with the intention of downstaging the tumor. Until rece...
