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Article
Open AccessNutrition or nature: using elementary flux modes to disentangle the complex forces sha** prokaryote pan-genomes
Microbial pan-genomes are shaped by a complex combination of stochastic and deterministic forces. Even closely related genomes exhibit extensive variation in their gene content. Understanding what drives this ...
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Article
Open AccessG-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis
G protein-coupled receptor (GPR)35 is highly expressed in the gastro-intestinal tract, predominantly in colon epithelial cells (CEC), and has been associated with inflammatory bowel diseases (IBD), suggesting ...
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Article
Open AccessMetabolic models predict bacterial passengers in colorectal cancer
Colorectal cancer (CRC) is a complex multifactorial disease. Increasing evidence suggests that the microbiome is involved in different stages of CRC initiation and progression. Beyond specific pro-oncogenic me...
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Article
Open AccessAntibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer
Antibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of anti...
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Article
Open AccessRAS testing practices and RAS mutation prevalence among patients with metastatic colorectal cancer: results from a Europe-wide survey of pathology centres
Treatment options for patients with metastatic colorectal cancer (mCRC) include anti-epithelial growth factor therapies, which, in Europe, are indicated in patients with RAS wild-type tumours only and require pri...
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Reference Work Entry In depth
Colorectal Cancer-Associated Microbiota
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Living Reference Work Entry In depth
Colorectal Cancer-Associated Microbiota
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Article
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
Recent high-throughput sequencing studies have provided a first glimpse of the microbiome associated with late-stage colorectal cancer. In this Opinion article, Tjalsma and colleagues present a driver–passenge...
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Chapter
Streptococcus bovis and Colorectal Cancer
The most salient feature of Streptococcus bovis (SB) is its clinical association with malignancy of the colon and rectum. The relationship between SB and colorectal cancer (CRC) was already recognized in the 1950...
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Article
Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin
Systemic chemotherapy has limited success in treating liver metastasis of colorectal cancer. Alternative approaches such as hepatic arterial infusion or trans arterial chemoembolisation aim to deliver the chem...
